Cytokines Recombinant Proteins
Human sIL 2R Recombinant Protein (RPPB0486)
- SKU:
- RPPB0486
Description
| Product Name: | Human sIL 2R Recombinant Protein |
| Product Code: | RPPB0486 |
| Size: | 10µg |
| Species: | Human |
| Target: | sIL 2R |
| Synonyms: | CD25, IL2R, TCGFR, IL-2RA, sIL-2RA, TAC antigen, sIL-2R, IDDM10, p55. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile colorless liquid formulation. |
| Formulation: | IL-2R His-Tag protein is supplied in 1x PBS and 50% glycerol pH 7.4. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
IL2-Ra is one of the three constituent subunits of the IL2 receptor. IL-2Ra is released into the serum after increased cellular expression such as increased activation of B and T cells. Clinical manifestations of IL2-Ra elevation include autoimmune conditions and some leukemias and lymphomas.
Interleukin-2R Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (22-213) corresponding to the mature IL2-R protein with an amino terminal hexahistidine tag.The IL-2R is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: plasma membrane Molecular Function:interleukin-2 binding; Ras guanyl-nucleotide exchange factor activity Biological Process: apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; MAPKKK cascade; regulation of T cell tolerance induction Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of |
| NCBI Summary: | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] |
| UniProt Code: | P01589 |
| NCBI GenInfo Identifier: | 124317 |
| NCBI Gene ID: | 3559 |
| NCBI Accession: | P01589.1 |
| UniProt Secondary Accession: | P01589,Q5W007, |
| UniProt Related Accession: | P01589 |
| Molecular Weight: | 30,819 Da |
| NCBI Full Name: | Interleukin-2 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 2 receptor subunit alpha |
| NCBI Official Symbol: | IL2RA�� |
| NCBI Official Synonym Symbols: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10�� |
| NCBI Protein Information: | interleukin-2 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-2 receptor subunit alpha |
| UniProt Synonym Protein Names: | TAC antigen; p55; CD_antigen: CD25 |
| UniProt Gene Name: | IL2RA�� |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Uniprot: |
P01589 |
Research Area: |
Cytokines |
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