Human SIKE1 Recombinant Protein (RPPB4684)

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SKU:
RPPB4684
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BRV8

Description

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Product Name:Human SIKE1 Recombinant Protein
Product Code:RPPB4684
Size:10µg
Species:Human
Target:SIKE1
Synonyms:Suppressor Of IKBKE 1, SIKE, Suppressor Of IKK Epsilon, SuppressorOf IKK-Epsilon.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SIKE1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30%glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSCTIEK ILTDAKTLLE RLREHDAAAE SLVDQSAALH RRVAAMREAGTALPDQYQED ASDMKDMSKY KPHILLSQEN TQIRDLQQEN RELWISLEEH QDALELIMSK YRKQMLQLMVAKKAVDAEPV LKAHQSHSAE IESQIDRICE MGEVMRKAVQ VDDDQFCKIQ EKLAQLELEN KELRELLSIS SESLQARKEN SMDTASQAIK
UniProt Code:Q9BRV8

Suppressor of IKBKE 1 also known as SIKE1 belongs to the SIKE family. SIKE interacts with IKK-epsilon and TBK1 and function as a suppressor of TLR3. In addition, SIKE1 perform by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 andDDX58/RIG-I. SIKE1 does not inhibit NF-kappa-B activation pathways.

SIKE1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 230 amino acids (1-207 a.a) andhaving a molecular mass of 26.1kDa.SIKE1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

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