Metabolism Recombinant Proteins

Human SHMT1 Recombinant Protein (RPES4467)

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SKU:
RPES4467
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Metabolism

Description

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Human SHMT1 Recombinant Protein

Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to the NMDA receptor and this could be a mechanism behind Smith-Magenis syndrome.

Product Name:Human SHMT1 Recombinant Protein (RPES4467)
Product Code:RPES4467
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Serine Hydroxymethyltransferase Cytosolic, SHMT, Glycine Hydroxymethyltransferase, Serine Methylase, SHMT1
Accession:P34896
Sequence:Met3-Phe483
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Serine Hydroxymethyltransferase Cytosolic is produced by our Mammalian expression system and the target gene encoding Met3-Phe483 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:53.9 kDa
AP Mol Mass:55 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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