Human SH3BGRL3 Recombinant Protein (RPPB4674)
- SKU:
- RPPB4674
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H299
Description
| Product Name: | Human SH3BGRL3 Recombinant Protein |
| Product Code: | RPPB4674 |
| Size: | 20µg |
| Species: | Human |
| Target: | SH3BGRL3 |
| Synonyms: | SH3 Domain Binding Glutamic Acid-Rich Protein Like 3, SH3BGRL3-Like Protein, SH3 Domain-Binding Protein 1, SH3BP-1, TNF Inhibitory Protein, TIP-B1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SH3BGRL3 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSGLRVY STSVTGSREI KSQQSEVTRI LDGKRIQYQL VDISQDNALR DEMRALAGNP KATPPQIVNG DQYCGDYELF VEAVEQNTLQ EFLKLA |
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) which is located on chromosome 1p34.3-35, encodes for a small 93 amino acids protein. SH3BGRL3 is the newest member of thioredoxin super family, whose posttranslational altered form was recognized as TNF-alpha inhibitory protein. SH3BGRL3 may act as a regulator in all-trans retinoic acid-induced pathway and also as a modulator of glutaredoxin biological activity.
SH3BGRL3 Human Recombinant produced in E. coli is a single polypeptide chain containing 116 amino acids (1-93) and having a molecular mass of 12.8 kDa.SH3BGRL3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SH3BGRL3: Could act as a modulator of glutaredoxin biological activity. Belongs to the SH3BGR family.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p36.11Cellular Component: lamellipodiumMolecular Function: GTPase activator activity; semaphorin receptor bindingBiological Process: positive regulation of GTPase activity; regulation of actin cytoskeleton organization and biogenesis; regulation of actin filament depolymerization; regulation of blood vessel endothelial cell migration |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H299 |
| NCBI GenInfo Identifier: | 24638222 |
| NCBI Gene ID: | 83442 |
| NCBI Accession: | Q9H299.1 |
| UniProt Secondary Accession: | Q9H299,Q5T122 |
| UniProt Related Accession: | Q9H299 |
| Molecular Weight: | 10,438 Da |
| NCBI Full Name: | SH3 domain-binding glutamic acid-rich-like protein 3 |
| NCBI Synonym Full Names: | SH3 domain binding glutamate rich protein like 3 |
| NCBI Official Symbol: | SH3BGRL3�� |
| NCBI Official Synonym Symbols: | TIP-B1; SH3BP-1; HEL-S-297�� |
| NCBI Protein Information: | SH3 domain-binding glutamic acid-rich-like protein 3 |
| UniProt Protein Name: | SH3 domain-binding glutamic acid-rich-like protein 3 |
| UniProt Synonym Protein Names: | SH3 domain-binding protein 1; SH3BP-1 |
| Protein Family: | SH3 domain-binding glutamic acid-rich-like protein |
| UniProt Gene Name: | SH3BGRL3�� |
| UniProt Entry Name: | SH3L3_HUMAN |
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