Human SGCB Recombinant Protein (RPPB4659)

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SKU:
RPPB4659
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16585

Description

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Product Name:Human SGCB Recombinant Protein
Product Code:RPPB4659
Size:20µg
Species:Human
Target:SGCB
Synonyms:Beta-sarcoglycan, Beta-SG, 43 kDa dystrophin-associatedglycoprotein, 43DAG, A3b, LGMD2E, Sarcoglycan, Beta (43kDaDystrophin-Associated Glycoprotein), Limb Girdle Muscular Dystrophy 2E(Non-Linked Families), SGC.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SGCB protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer(pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSWAVIRIGPNGCDSMEFH ESGLLRFKQV SDMGVIHPLY KSTVGGRRNE NLVITGNNQP IVFQQGTTKL SVENNKTSITSDIGMQFFDP RTQNILFSTD YETHEFHLPS GVKSLNVQKA STERITSNAT SDLNIKVDGR AIVRGNEGVFIMGKTIEFHM GGNMELKAEN SIILNGSVMV STTRLPSSSS GDQLGSGDWV RYKLCMCADG TLFKVQVTSQNMGCQISDNP CGNTH

SarcoglycanBeta, also known as SGCB, is a part of the sarcoglycan family. SGCB belongs to thesarcoglycan complex which is a subcomplex of the dystrophin-glycoproteincomplex that connects between the F-actin cytoskeleton and the extracellularmatrix.

SGCB Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 255 amino acids (87-318 a.a) andhaving a molecular mass of 27.8kDa.SGCB is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:SGCB: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCB are the cause of limb-girdle muscular dystrophy type 2E (LGMD2E). LGMD2E is an autosomal recessive disorder. Belongs to the sarcoglycan beta/delta/gamma/zeta family.
UniProt Protein Details:

Protein type:Dystrophin complex; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; integral to plasma membrane; cytoplasm; sarcoglycan complex; sarcolemma

Biological Process: muscle development; cardiac muscle cell development; muscle fiber development

Disease: Muscular Dystrophy, Limb-girdle, Type 2e

NCBI Summary:This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
UniProt Code:Q16585
NCBI GenInfo Identifier:13431857
NCBI Gene ID:6443
NCBI Accession:Q16585.1
UniProt Secondary Accession:Q16585,O00661, B7Z635,
UniProt Related Accession:Q16585
Molecular Weight:318
NCBI Full Name:Beta-sarcoglycan
NCBI Synonym Full Names:sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
NCBI Official Symbol:SGCB��
NCBI Official Synonym Symbols:A3b; SGC; LGMD2E��
NCBI Protein Information:beta-sarcoglycan; 43DAG; beta-SG; 43 kDa dystrophin-associated glycoprotein; limb girdle muscular dystrophy 2E (non-linked families); beta-sarcoglycan(43kD dystrophin-associated glycoprotein)
UniProt Protein Name:Beta-sarcoglycan
UniProt Synonym Protein Names:43 kDa dystrophin-associated glycoprotein; 43DAG; A3b
Protein Family:Beta-sarcoglycan
UniProt Gene Name:SGCB��
UniProt Entry Name:SGCB_HUMAN
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