Human SFRP2 Recombinant Protein (RPPB4654)
- SKU:
- RPPB4654
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96HF1
Description
| Product Name: | Human SFRP2 Recombinant Protein |
| Product Code: | RPPB4654 |
| Size: | 20µg |
| Species: | Human |
| Target: | SFRP2 |
| Synonyms: | FRP-2, SARP1, SDF-5, Secreted frizzled-related protein 2,UNQ361/PRO697, FKSG12, FKSG12. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SFRP2 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSARGLFLF GQPDFSYKRS NCKPIPVNLQ LCHGIEYQNM RLPNLLGHET MKEVLEQAGAWIPLVMKQCH PDTKKFLCSL FAPVCLDDLD ETIQPCHSLC VQVKDRCAPV MSAFGFPWPD MLECDRFPQDNDLCIPLASS DHLLPATEEA PKVCEACKNK NDDDNDIMET LCKNDFALKI KVKEITYINR DTKIILETKS KTIYKLNGVSERDLKKSVLW LKDSLQCTCE EMNDINAPYL VMGQKQGGEL VITSVKRWQK GQREFKRISR SIRKLQC |
Secreted frizzled-relatedprotein 2 (SFRP2) belongs to the SFRP family which contains a cysteine-richdomain homologous to the putative Wnt-binding site of Frizzled proteins. SFRP2function as soluble modulators of Wnt signaling. Methylation of SFRP2 is apossible marker for the existence of colorectal cancer.
SFRP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids (20-295 a.a) and having a molecular mass of 33.8kDa.SFRP2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SFRP2: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Belongs to the secreted frizzled-related protein (sFRP) family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: extracellular matrix; extracellular space; integral to membrane Molecular Function:G-protein coupled receptor activity; integrin binding; Wnt-protein binding; Wnt receptor activity; fibronectin binding; receptor agonist activity Biological Process: convergent extension involved in axis elongation; collagen fibril organization; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; negative regulation of caspase activity; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; cell-cell signaling; negative regulation of mesodermal cell fate specification; positive regulation of cell proliferation; negative regulation of cell migration; response to nutrient; negative regulation of epithelial cell proliferation; response to drug; negative regulation of JNK activity; negative regulation of peptidyl-tyrosine phosphorylation; male gonad development; positive regulation of cell adhesion mediated by integrin; digestive tract morphogenesis; chondrocyte development; positive regulation of peptidyl-serine phosphorylation; positive regulation of cell growth; patterning of blood vessels; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; neural tube closure; cellular response to extracellular stimulus; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96HF1 |
| NCBI GenInfo Identifier: | 61216828 |
| NCBI Gene ID: | 6423 |
| NCBI Accession: | Q96HF1.2 |
| UniProt Secondary Accession: | Q96HF1,O14778, Q9HAP5, B3KQR2, |
| UniProt Related Accession: | Q96HF1 |
| Molecular Weight: | 295 |
| NCBI Full Name: | Secreted frizzled-related protein 2 |
| NCBI Synonym Full Names: | secreted frizzled-related protein 2 |
| NCBI Official Symbol: | SFRP2�� |
| NCBI Official Synonym Symbols: | FRP-2; SARP1; SDF-5�� |
| NCBI Protein Information: | secreted frizzled-related protein 2; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
| UniProt Protein Name: | Secreted frizzled-related protein 2 |
| UniProt Synonym Protein Names: | Secreted apoptosis-related protein 1; SARP-1 |
| Protein Family: | Secreted frizzled-related protein |
| UniProt Gene Name: | SFRP2�� |
| UniProt Entry Name: | SFRP2_HUMAN |
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