Human SESN1 / Sestrin-1 ELISA Kit

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SKU:
HUFI00684
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q9Y6P5
Sensitivity:
0.375ng/ml
Range:
0.625-40ng/ml
ELISA Type:
Sandwich
Synonyms:
SESN1, Sestrin-1, PA26, SEST1, p53-regulated protein PA26,
Reactivity:
Human
Research Area:
Cell Biology

Description

Human SESN1 / Sestrin-1 ELISA

SESN1 / Sestrin-1 is induced by the p53 tumor suppressor protein and plays a role in the cellular response to DNA damage and oxidative stress. SESN1 / Sestrin-1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. SESN1 / Sestrin-1 also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of SESN1 / Sestrin-1 is a potential marker for exposure to radiation.

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