The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. SEMA4B is a single-pass type I membrane protein and contains one Ig-like C2-type (immunoglobulin-like) domain; one PSI domain and one Sema domain. Human SEMA4B is expressed in neurons. SEMA4B inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. SEMA4B negatively regulates basophil-mediated Th2 and humoral memory responses.
Product Name:
Human SEMA4B Recombinant Protein (RPES4256)
Product Code:
RPES4256
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Semaphorin-4B, KIAA1745, SEMAC and SEMA4B
Accession:
Q9NPR2
Sequence:
Leu39-Glu712
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Semaphorin 4B is produced by our Mammalian expression system and the target gene encoding Leu39-Glu712 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
75.7 kDa
AP Mol Mass:
86 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
system_update_altDatasheetHuman SEMA4B Recombinant Protein Semaphorin-4B is a single-pass type I membrane protein. SEMA4B is a member of the semaphorin family. The class 4 semaphorins are integra