Hormones Recombinant Proteins
Human Secretin Recombinant Protein (RPPB1371)
- SKU:
- RPPB1371
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09683
- Research Area:
- Hormones
Description
| Product Name: | Human Secretin Recombinant Protein |
| Product Code: | RPPB1371 |
| Size: | 5mg |
| Species: | Human |
| Target: | Secretin |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1mg/ml) was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Secretin in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Secretin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Secretin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
Human Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the production of gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes from the pancreas triggered by cholecystokinin.
Secretin has a molecular formula of C130H220N44O41, a.a. sequence of H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg- Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 and having an Mw of 3055.4 Dalton.
| UniProt Protein Function: | SCT: Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach. Belongs to the glucagon family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: extracellular region Molecular Function:hormone activity Biological Process: dentate gyrus development; visual learning; negative regulation of neuron apoptosis; pancreatic juice secretion |
| NCBI Summary: | Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09683 |
| NCBI GenInfo Identifier: | 12231018 |
| NCBI Gene ID: | 6343 |
| NCBI Accession: | P09683.2 |
| UniProt Related Accession: | P09683 |
| Molecular Weight: | 13,016 Da |
| NCBI Full Name: | Secretin |
| NCBI Synonym Full Names: | secretin |
| NCBI Official Symbol: | SCT�� |
| NCBI Protein Information: | secretin; prepro-secretin |
| UniProt Protein Name: | Secretin |
| Protein Family: | Secretin |
| UniProt Gene Name: | SCT�� |
| UniProt Entry Name: | SECR_HUMAN |
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