Human SEC61B Recombinant Protein (RPPB4611)

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SKU:
RPPB4611
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P60468

Description

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Product Name:Human SEC61B Recombinant Protein
Product Code:RPPB4611
Size:10µg
Species:Human
Target:SEC61B
Synonyms:Protein transport protein Sec61 subunit beta, SEC61B, Sec61 Beta Subunit, Protein Translocation Complex Beta, Protein Transport Protein SEC61 Beta Subunit, Sec61 Complex Beta Subunit.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SEC61B protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPGPTPS GTNVGSSGRS PSKAVAARAA GSTVRQRKNA SCGTRSAGRT TSAGTGGMWR FYTEDSPGLK VGP

The Sec61 complex is the key component of the protein translocation apparatus of the ER (endoplasmic reticulum) membrane. Oligomers of the Sec61 complex construct a transmembrane channel where proteins are translocated across and incorporated into the ER membrane. This complex consists of 3 membrane proteins- alpha, beta, and gamma. The SEC61B gene encodes the beta-subunit protein. The Sec61 subunits are also detected in the post-ER compartment, suggesting that these proteins can get out of the ER and recycle back.

SEC61B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids (1-70 a.a) and having a molecular mass of 9.4kDa.SEC61B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SEC61B: Necessary for protein translocation in the endoplasmic reticulum. Belongs to the SEC61-beta family.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q22.33

Cellular Component: membrane; endoplasmic reticulum; integral to membrane

Molecular Function:protein binding; epidermal growth factor binding

Biological Process: retrograde protein transport, ER to cytosol; SRP-dependent cotranslational protein targeting to membrane; antigen processing and presentation of peptide antigen via MHC class I; ER-associated protein catabolic process; cellular protein metabolic process; translation; protein import into nucleus, translocation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression

NCBI Summary:The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
UniProt Code:P60468
NCBI GenInfo Identifier:42560366
NCBI Gene ID:10952
NCBI Accession:P60468.2
UniProt Related Accession:P60468
Molecular Weight:
NCBI Full Name:Protein transport protein Sec61 subunit beta
NCBI Synonym Full Names:SEC61 translocon beta subunit
NCBI Official Symbol:SEC61B��
NCBI Protein Information:protein transport protein Sec61 subunit beta
UniProt Protein Name:Protein transport protein Sec61 subunit beta
UniProt Gene Name:SEC61B��
UniProt Entry Name:SC61B_HUMAN
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