Human SEC22B Recombinant Protein (RPPB4609)

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SKU:
RPPB4609
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75396

Description

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Product Name:Human SEC22B Recombinant Protein
Product Code:RPPB4609
Size:20µg
Species:Human
Target:SEC22B
Synonyms:SEC22 Vesicle Trafficking Protein Homolog B (S. Cerevisiae) Gene/Pseudogene, SEC22 Vesicle Trafficking Protein-Like 1 (S. Cerevisiae), ER-Golgi SNARE Of 24 KDa, SEC22L1, ERS-24.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SEC22B solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea, 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSM LPLAAS MQEDEQSGRD LQQYQSQAKQ LFRKLNEQSP TRCTLEAGAM TFHYIIEQGV CYLVLCEAAF PKKLAFAYLE DLHSEFDEQH GKKVPTVSRP YSFIEFDTFI QKTKKLYIDS RARRNLGSIN TELQDVQRIM VANIEEVLQR GEALSALDSK ANNLSSLSKK YRQDAKYLNM RSTYA

Vesicle-trafficking protein SEC22b precursor (SEC22B) is a member of the synaptobrevin family. SEC22B forms a complex with SNARE and it is believed to have a role in the ER-Golgi protein trafficking. SEC22B has a strong similarity to the mouse and Chinese hamster proteins.

SEC22B Human Recombinant produced in E. coli is a single polypeptide chain containing 205 amino acids (14-194) and having a molecular mass of 23.3 kDa.SEC22B is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SEC22B: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. Belongs to the synaptobrevin family.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to membrane; ER-Golgi intermediate compartment; melanosome

Molecular Function:protein binding; syntaxin binding

Biological Process: ER to Golgi vesicle-mediated transport; protein transport; positive regulation of protein catabolic process; regulation of organelle organization and biogenesis

NCBI Summary:The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]
UniProt Code:O75396
NCBI GenInfo Identifier:317373544
NCBI Gene ID:9554
NCBI Accession:O75396.4
UniProt Related Accession:O75396
Molecular Weight:
NCBI Full Name:Vesicle-trafficking protein SEC22b
NCBI Synonym Full Names:SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
NCBI Official Symbol:SEC22B��
NCBI Official Synonym Symbols:ERS-24; SEC22L1��
NCBI Protein Information:vesicle-trafficking protein SEC22b
UniProt Protein Name:Vesicle-trafficking protein SEC22b
UniProt Synonym Protein Names:ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1
Protein Family:Vesicle-trafficking protein
UniProt Gene Name:SEC22B��
UniProt Entry Name:SC22B_HUMAN
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