Human SEC13 Recombinant Protein (RPPB4608)
- SKU:
- RPPB4608
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P55735
Description
| Product Name: | Human SEC13 Recombinant Protein |
| Product Code: | RPPB4608 |
| Size: | 20µg |
| Species: | Human |
| Target: | SEC13 |
| Synonyms: | Protein SEC13 homolog, SEC13-like protein 1, SEC13-related protein, SEC13, D3S1231E, SEC13L1, SEC13R, npp-20. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SEC13 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWREEN GTWEKSHEHA GHDSSVNSVC WAPHDYGLIL ACGSSDGAIS LLTYTGEGQW EVKKINNAHT IGCNAVSWAPAVVPGSLIDH PSGQKPNYIK RFASGGCDNL IKLWKEEEDG QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV FIWTCDDASS NTWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI SDVNKGQGSV SASVTEGQQN EQ |
SEC13 is a member of the SEC13 family of WD-repeat proteins. SEC13 is a constituent of the endoplasmic reticulum and the nuclear pore complex. SEC13 is similar to the yeast SEC13 protein that is essential for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. SEC13 interacts with SEC31A and SEC31B. SEC31A colocalizes with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function.
SEC13 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 342 amino acids (1-322 a.a.) and having a molecular mass of 37.7kDa. The SEC13 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SEC13: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Belongs to the WD repeat SEC13 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3p25-p24 Cellular Component: cytosol; endoplasmic reticulum membrane; intracellular membrane-bound organelle; kinetochore; nuclear envelope; nucleoplasm Molecular Function:protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; positive regulation of TOR signaling pathway; sister chromatid cohesion |
| NCBI Summary: | The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P55735 |
| NCBI GenInfo Identifier: | 50403748 |
| NCBI Gene ID: | 6396 |
| NCBI Accession: | P55735.3 |
| UniProt Secondary Accession: | P55735,Q5BJF0, Q9BRM6, Q9BUG7, A8MV37, B4DXJ1, |
| UniProt Related Accession: | P55735 |
| Molecular Weight: | 40,747 Da |
| NCBI Full Name: | Protein SEC13 homolog |
| NCBI Synonym Full Names: | SEC13 homolog, nuclear pore and COPII coat complex component |
| NCBI Official Symbol: | SEC13�� |
| NCBI Official Synonym Symbols: | SEC13R; npp-20; SEC13L1; D3S1231E�� |
| NCBI Protein Information: | protein SEC13 homolog |
| UniProt Protein Name: | Protein SEC13 homolog |
| UniProt Synonym Protein Names: | SEC13-like protein 1; SEC13-related protein |
| Protein Family: | Protein transport protein |
| UniProt Gene Name: | SEC13�� |
| UniProt Entry Name: | SEC13_HUMAN |
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