Human SCGB3A2 Recombinant Protein (RPPB4594)

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SKU:
RPPB4594
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96PL1

Description

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Product Name:Human SCGB3A2 Recombinant Protein
Product Code:RPPB4594
Size:10µg
Species:Human
Target:SCGB3A2
Synonyms:Secretoglobin, Family 3A Member 2, Uteroglobin-Related Protein 1, Pneumo Secretory Protein 1, UGRP1, PnSP-1, PNSP1, Secretoglobin Family 3A Member 2, Uteroglobin Related Protein 1, LU103, SCGB3A2.
Source:Escherichia Coli
Physical Appearance:Filtered colorless solution.
Formulation:SCGB3A2 solution at a concentration of 0.4mg/ml in phosphate buffered saline (PBS) pH 8.0.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MFLINKVPLP VDKLAPLPLD NILPFMDPLK LLLKTLGISV EHLVEGLRKC VNELGPEASE AVKKLLEALS HLVGGSGGSF LINKVPLPVD KLAPLPLDNI LPFMDPLKLL LKTLGISVEH LVEGLRKCVN ELGPEASEAV KKLLEALSHL VHHHHHH

Secretoglobin Family 3A Member 2 (SCGB3A2) is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of the SCGB3A2 gene results in susceptibility to asthma.

SCGB3A2 Human Recombinant produced in E.Coli is a non-glycosylated homodimer containing a total of 157 (2xPhe22-Val93) amino acids including a 6 aa linker and 6 aa His tag at C-terminus. The total calculated molecular mass is 17.1kDa.

UniProt Protein Function:Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
NCBI Summary:The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]
UniProt Code:Q96PL1
NCBI GenInfo Identifier:16876445
NCBI Gene ID:117156
NCBI Accession:NP_473364.1
UniProt Related Accession:Q96PL1
Molecular Weight:Molecular Mass: 7.9 kDaActual Protein Molecular Mass: 7 kDa
NCBI Full Name:secretoglobin family 3A member 2
NCBI Synonym Full Names:secretoglobin family 3A member 2
NCBI Official Symbol:SCGB3A2��
NCBI Official Synonym Symbols:LU103; PNSP1; UGRP1; pnSP-1��
NCBI Protein Information:secretoglobin family 3A member 2
UniProt Protein Name:Secretoglobin family 3A member 2
UniProt Synonym Protein Names:Pneumo secretory protein 1; PnSP-1; Uteroglobin-related protein 1
UniProt Gene Name:SCGB3A2��
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