Human SAR1B Recombinant Protein (RPPB4585)

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RPPB4585

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Product Name:Human SAR1B Recombinant Protein
Product Code:RPPB4585
Size:20µg
Species:Human
Target:SAR1B
Synonyms:GTP-binding protein SAR1b, GTP-binding protein B, GTBPB, SAR1B, SARA2, SARB, ANDD, CMRD.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SAR1B protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSFIFDW IYSGFSSVLQ FLGLYKKTGK LVFLGLDNAG KTTLLHMLKD DRLGQHVPTL HPTSEELTIA GMTFTTFDLG GHVQARRVWK NYLPAINGIV FLVDCADHER LLESKEELDS LMTDETIANV PILILGNKID RPEAISEERL REMFGLYGQT TGKGSISLKE LNARPLEVFM CSVLKRQGYG EGFRWMAQYI D

SAR1B is a small GTPase that functions as a homodimer. GTP-Binding Protein SAR1B (SAR1b) is involved in transport from the endoplasmic reticulum to the Golgi apparatus and also in the selection of the protein cargo and the assembly of the COPII coat complex. The SAR1B protein is activated by the guanine nucleotide exchange factor PREB. SAR1B gene defects are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD).

SAR1B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-198 a.a) and having a molecular mass of 24.8kDa.SAR1B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SAR1B: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD); also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Belongs to the small GTPase superfamily. SAR1 family.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric, SAR1; G protein, monomeric; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytosol; endoplasmic reticulum membrane

Molecular Function:GTP binding; GTPase activity; metal ion binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine

Disease: Chylomicron Retention Disease

NCBI Summary:The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Code:Q9Y6B6
NCBI GenInfo Identifier:14285769
NCBI Gene ID:51128
NCBI Accession:Q9Y6B6.1
UniProt Secondary Accession:Q9Y6B6,Q567T4, D3DQA4,
UniProt Related Accession:Q9Y6B6
Molecular Weight:22,410 Da
NCBI Full Name:GTP-binding protein SAR1b
NCBI Synonym Full Names:secretion associated Ras related GTPase 1B
NCBI Official Symbol:SAR1B��
NCBI Official Synonym Symbols:ANDD; CMRD; GTBPB; SARA2��
NCBI Protein Information:GTP-binding protein SAR1b
UniProt Protein Name:GTP-binding protein SAR1b
UniProt Synonym Protein Names:GTP-binding protein B; GTBPB
Protein Family:GTP-binding protein
UniProt Gene Name:SAR1B��
UniProt Entry Name:SAR1B_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y6B6
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