Human SAR1A Recombinant Protein (RPPB4584)

(No reviews yet) Write a Review
SKU:
RPPB4584
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NR31

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human SAR1A Recombinant Protein
Product Code:RPPB4584
Size:20µg
Species:Human
Target:SAR1A
Synonyms:GTP-binding protein SAR1a, COPII-associated small GTPase, SAR1A, SAR1, SARA, SARA1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SAR1A solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID

SAR1A is a member of the small GTPase superfamily. SAR1A is a vital component of COPII vesicle coats involved in export of cargo from the ER (Endoplasmic Reticulum). The GTPase activity of SAR1A serves as a molecular switch to control protein-protein and protein-lipid interactions which dictate vesicle budding from the ER. SAR1A, while GDP-bound interacts with the membrane-bound exchange factor Sec12 and trades its bound GDP for GTP. SAR1A is also involved in the transport from the ER to the Golgi apparatus. SAR1A is required to maintain SEC16A localization at distinct locations on the ER membrane possibly by preventing its dissociation. SAR1A-GTP-dependent compilation of SEC16A on the ER membrane creates a structured scaffold defining endoplasmic reticulum exit sites.

SAR1A Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 218 amino acids (1- 198 a.a.) and having a molecular mass of 24.5kDa.The SAR1A is purified by proprietary chromatographic techniques.

UniProt Protein Function:SAR1A: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). Belongs to the small GTPase superfamily. SAR1 family.
UniProt Protein Details:

Protein type:G protein, monomeric; G protein, monomeric, SAR1; G protein

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: Golgi apparatus; sarcoplasmic reticulum

Molecular Function:GTP binding

Biological Process: vesicle-mediated transport; intracellular protein transport

UniProt Code:Q9NR31
NCBI GenInfo Identifier:14548013
NCBI Gene ID:56681
NCBI Accession:Q9NR31.1
UniProt Related Accession:Q9NR31
Molecular Weight:
NCBI Full Name:GTP-binding protein SAR1a
NCBI Synonym Full Names:secretion associated Ras related GTPase 1A
NCBI Official Symbol:SAR1A��
NCBI Official Synonym Symbols:SAR1; Sara; SARA1; masra2��
NCBI Protein Information:GTP-binding protein SAR1a
UniProt Protein Name:GTP-binding protein SAR1a
UniProt Synonym Protein Names:COPII-associated small GTPase
Protein Family:GTP-binding protein
UniProt Gene Name:SAR1A��
UniProt Entry Name:SAR1A_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products