Human SAMSN1 Recombinant Protein (RPPB4582)

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SKU:
RPPB4582
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NSI8

Description

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Product Name:Human SAMSN1 Recombinant Protein
Product Code:RPPB4582
Size:10µg
Species:Human
Target:SAMSN1
Synonyms:HACS1, NASH1, SASH2, SH3D6B, SLy2, SAM domain-containing protein SAMSN-1, Hematopoietic adaptor containing SH3 and SAM domains 1, Nash1, SAM domain, SH3 domain and nuclear localization signals protein 1, SH3-SAM adaptor protein, SAMSN1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SAMSN1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMLKRKPS NVSEKEKHQK PKRSSSFGNF DRFRNNSLSK PDDSTEAHEG DPTNGSGEQS KTSNNGGGLG KKMRAISWTM KKKVGKKYIK ALSEEKDEED GENAHPYRNS DPVIGTHTEK VSLKASDSMD SLYSGQSSSS GITSCSDGTS NRDSFRLDDD GPYSGPFCGR ARVHTDFTPS PYDTDSLKIK KGDIIDIICK TPMGMWTGML NNKVGNFKFI YVDVISEEEA APKKIKANRR SNSKKSKTLQ EFLERIHLQE YTSTLLLNGY ETLEDLKDIK ESHLIELNIE NPDDRRRLLS AAENFLEEEI IQEQENEPEP LSLSSDISLN KSQLDDCPRD SGCYISSGNS DNGKEDLESE NLSDMVHKII ITEPSD

SAM Domain SH3 Domain and Nuclear Localization Signal 1 (SAMSN1) is a member of a known adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains. SAMSN1 is a negative regulator of B-cell activation and is down-regulates cell proliferation. SAMSN1 is up-regulated by IL-4 in activated B cells and expressed mainly in dendritic cells. SAMSN1 owns a function which is similar to other adaptor proteins that link signaling molecules in signal transduction cascades.

SAMSN1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 396 amino acids (1-373a.a) and having a molecular mass of 44.1kDa. SAMSN1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SAMSN1: an adaptor and scaffold protein containing an SH3 and a SAM (sterile alpha motif) domain. Its expression is induced by B cell activation signals. Two alternatively spliced isoforms have been described.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 21q11Cellular Component: ruffle; cytosol; nucleusMolecular Function: phosphotyrosine bindingBiological Process: negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of adaptive immune response; negative regulation of B cell activation
UniProt Protein Details:
NCBI Summary:SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9NSI8
NCBI GenInfo Identifier:48762709
NCBI Gene ID:64092
NCBI Accession:NP_071419.3
UniProt Secondary Accession:Q9NSI8,Q8NFF7, Q9C041, B3KWJ3, F8WAA1
UniProt Related Accession:Q9NSI8
Molecular Weight:49,627 Da
NCBI Full Name:SAM domain-containing protein SAMSN-1 isoform 1
NCBI Synonym Full Names:SAM domain, SH3 domain and nuclear localization signals 1
NCBI Official Symbol:SAMSN1��
NCBI Official Synonym Symbols:SLy2; HACS1; NASH1; SASH2; SH3D6B��
NCBI Protein Information:SAM domain-containing protein SAMSN-1
UniProt Protein Name:SAM domain-containing protein SAMSN-1
UniProt Synonym Protein Names:Hematopoietic adaptor containing SH3 and SAM domains 1; Nash1; SAM domain, SH3 domain and nuclear localization signals protein 1; SH3-SAM adaptor protein
Protein Family:SAM domain-containing protein
UniProt Gene Name:SAMSN1��
UniProt Entry Name:SAMN1_HUMAN
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