Human S100P Recombinant Protein (RPPB4578)
- SKU:
- RPPB4578
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P25815
Description
| Product Name: | Human S100P Recombinant Protein |
| Product Code: | RPPB4578 |
| Size: | 25µg |
| Species: | Human |
| Target: | S100P |
| Synonyms: | Protein S100-E, S100E, Migration-Inducing Gene 9, MIG9. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | S100P Human solution (1mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT, 0.05M NaCl & 20% glycerol.� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MTELETAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK |
S100P is a Ca2+ binding protein that is part of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are found in the cytoplasm and/or nucleus of a large range of cells, and participates in the regulation of a number of cellular function such as cell cycle progression and differentiation. S100P participates in numerous biological functions but the exact functions or mechanism of its action is still mostly unknown. Once S100P binds calcium ions it goes through a conformational change that results in an exposure of a hydrophobic surface which permits the interaction with specific target proteins.
S100P Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 115 amino acids (1-95a.a.) and having a molecular mass of 12.6 kDa. S100P protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). |
| NCBI Summary: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25815 |
| NCBI GenInfo Identifier: | 134142 |
| NCBI Gene ID: | 6286 |
| NCBI Accession: | P25815.2 |
| UniProt Secondary Accession: | P25815,Q5J7W2, |
| UniProt Related Accession: | P25815 |
| Molecular Weight: | 10,400 Da |
| NCBI Full Name: | Protein S100-P |
| NCBI Synonym Full Names: | S100 calcium binding protein P |
| NCBI Official Symbol: | S100P�� |
| NCBI Official Synonym Symbols: | MIG9�� |
| NCBI Protein Information: | protein S100-P |
| UniProt Protein Name: | Protein S100-P |
| UniProt Synonym Protein Names: | Migration-inducing gene 9 protein; MIG9; Protein S100-E; S100 calcium-binding protein P |
| Protein Family: | Protein |
| UniProt Gene Name: | S100P�� |
| UniProt Entry Name: | S100P_HUMAN |
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