Human S100A7 Recombinant Protein (RPPB4562)

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SKU:
RPPB4562
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P31151

Description

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Product Name:Human S100A7 Recombinant Protein
Product Code:RPPB4562
Size:20µg
Species:Human
Target:S100A7
Synonyms:S100 calcium-binding protein A7 (psoriasin 1), S100A7c, PSOR1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:S100A7 protein at 0.5mg/ml in 20mM Tris-HCl, pH-8, 0.1M NaCl, 1mM DTT and 30% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSNTQAERSI IGMIDMFHKY TRRDDKIDKP SLLTMMKENFPNFLSACDKK GTNYLADVFE KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q

S100A7 is a member of the S-100 family of calcium binding proteins and is produced through a non-classical secretory pathway to the cytoplasm. S100A7 takes part in the regulation of several cellular courses, such as cell cycle, cell progression and cellular differentiation. S100A7 holds two EF-hand domains and is extremely upregulated in psoriatic epidermis, in addition to bladder squamous cell carcinoma and breast cancer tissue, signifying a probable part in carcinogenesis.

S100A7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 121 amino acids (1-101) and having a molecular mass of 13.6 kDa.The S100A4 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:S100A7: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: focal adhesion; endoplasmic reticulum; cytoplasm; extracellular region; nucleus; cytosol

Molecular Function:RAGE receptor binding; protein binding; zinc ion binding; calcium ion binding

Biological Process: keratinocyte differentiation; sequestering of metal ion; response to reactive oxygen species; epidermis development; innate immune response; response to lipopolysaccharide; angiogenesis; defense response to Gram-negative bacterium

NCBI Summary:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]
UniProt Code:P31151
NCBI GenInfo Identifier:172046820
NCBI Gene ID:6278
NCBI Accession:P31151.4
UniProt Secondary Accession:P31151,Q5SY67, Q6FGE3, Q9H1E2,
UniProt Related Accession:P31151
Molecular Weight:101
NCBI Full Name:Protein S100-A7
NCBI Synonym Full Names:S100 calcium binding protein A7
NCBI Official Symbol:S100A7��
NCBI Official Synonym Symbols:PSOR1; S100A7c��
NCBI Protein Information:protein S100-A7; psoriasin 1; S100 calcium-binding protein A7 (psoriasin 1)
UniProt Protein Name:Protein S100-A7
UniProt Synonym Protein Names:Psoriasin; S100 calcium-binding protein A7
Protein Family:Protein
UniProt Gene Name:S100A7��
UniProt Entry Name:S10A7_HUMAN
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