Human S100A5 Recombinant Protein (RPPB4558)

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RPPB4558

Description

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Product Name:Human S100A5 Recombinant Protein
Product Code:RPPB4558
Size:20µg
Species:Human
Target:S100A5
Synonyms:Protein S100-A5, Protein S-100D, S100 calcium-binding protein A5, S100A5, S100D.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The S100A5 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol, 0.1M NaCl and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES SIDDLMKSLD KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK

S100 calcium binding protein A5 (S100A5) belongs to the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family members are localized in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A5 has a Ca2+ affinity 20-100 fold higher than the other S100 proteins investigated under identical conditions. Furthermore, S100A5 protein binds Zn2+ and Cu2+, and Cu2+ strongly which harms the binding of Ca2+. S100A5 is expressed in very limited regions of the adult brain.

S100A5 Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�112 amino acids (1-92 a.a.) and having a molecular mass of 12.9kDa. The S100A5 is purified by proprietary chromatographic techniques.

UniProt Protein Function:S100A5: Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. Belongs to the S-100 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cell soma; nucleus

Molecular Function:protein homodimerization activity; copper ion binding; zinc ion binding; calcium ion binding

NCBI Summary:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]
UniProt Code:P33763
NCBI GenInfo Identifier:62739837
NCBI Gene ID:6276
NCBI Accession:AAH93957.1
UniProt Secondary Accession:P33763,Q5RHS3,
UniProt Related Accession:P33763
Molecular Weight:10,744 Da
NCBI Full Name:S100 calcium binding protein A5
NCBI Synonym Full Names:S100 calcium binding protein A5
NCBI Official Symbol:S100A5��
NCBI Official Synonym Symbols:S100D��
NCBI Protein Information:protein S100-A5; S100 calcium-binding protein A5
UniProt Protein Name:Protein S100-A5
UniProt Synonym Protein Names:Protein S-100D; S100 calcium-binding protein A5
Protein Family:Protein
UniProt Gene Name:S100A5��
UniProt Entry Name:S10A5_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P33763
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