Human S100A2 Recombinant Protein (RPPB4553)
- SKU:
- RPPB4553
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P29034
Description
| Product Name: | Human S100A2 Recombinant Protein |
| Product Code: | RPPB4553 |
| Size: | 20µg |
| Species: | Human |
| Target: | S100A2 |
| Synonyms: | Protein S100-A2, CAN19, Protein S-100L, S100 calcium-binding protein A2, S100A2, S100L, MGC111539. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The S100A2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 30% glycerol and 0.2M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MCSSLEQALA VLVTTFHKYS CQEGDKFKLS KGEMKELLHK ELPSFVGEKV DEEGLKKLMG SLDENSDQQV DFQEYAVFLA LITVMCNDFF QGCPDRP |
S100A2 belongs to the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A2 may function as a modulator against excess calcium accumulation in normal human mammary epithelial cells and also have a role in suppressing tumor cell growth. S100A2 may have a tumor suppressor function. S100 family members are localized in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Chromosomal rearrangements and altered expression of the S100A2 gene are implicated in breast cancer.
S100A2 Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�117 amino acids (1-97 a.a.) and having a molecular mass of 13.1kDa. The S100A2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. |
| NCBI Summary: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29034 |
| NCBI GenInfo Identifier: | 5174661 |
| NCBI Gene ID: | 6273 |
| NCBI Accession: | NP_005969.1 |
| UniProt Secondary Accession: | P29034,O00266, Q3KRB9, Q5RHS8, Q9BU83, |
| UniProt Related Accession: | P29034 |
| Molecular Weight: | 10 |
| NCBI Full Name: | protein S100-A2 |
| NCBI Synonym Full Names: | S100 calcium binding protein A2 |
| NCBI Official Symbol: | S100A2�� |
| NCBI Official Synonym Symbols: | CAN19; S100L�� |
| NCBI Protein Information: | protein S100-A2 |
| UniProt Protein Name: | Protein S100-A2 |
| UniProt Synonym Protein Names: | CAN19; Protein S-100L; S100 calcium-binding protein A2 |
| UniProt Gene Name: | S100A2�� |
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