Human S100A13 Recombinant Protein (RPPB4550)

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SKU:
RPPB4550
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q99584

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human S100A13 Recombinant Protein
Product Code:RPPB4550
Size:10µg
Species:Human
Target:S100A13
Synonyms:Protein S100-A13, S100 calcium-binding protein A13, S100A13.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:S100A13 protein at 1mg/ml in 20mM Tris-HCL, pH-8, 50mM NaCl and 20% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAAEPLTELE ESIETVVTTF FTFARQEGRK DSLSVNEFKE LVTQQLPHLL KDVGSLDEKM KSLDVNQDSE LKFNEYWRLI GELAKEIRKK KDLKIRKK

S100A13 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family members are localized in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A13 is extensively expressed in various types of tissues with an elevated expression level in the thyroid gland. In smooth muscle cells, S100A13 co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction.

S100A13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 118 amino acids (1-98) and having a molecular mass of 13.6 kDa.The S100A13 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
NCBI Summary:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q99584
NCBI GenInfo Identifier:66737368
NCBI Gene ID:6284
NCBI Accession:NP_001019381.1
UniProt Secondary Accession:Q99584,Q52PI9, Q6FGF8,
UniProt Related Accession:Q99584
Molecular Weight:10
NCBI Full Name:protein S100-A13
NCBI Synonym Full Names:S100 calcium binding protein A13
NCBI Official Symbol:S100A13��
NCBI Protein Information:protein S100-A13
UniProt Protein Name:Protein S100-A13
UniProt Synonym Protein Names:S100 calcium-binding protein A13
UniProt Gene Name:S100A13��
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system_update_altDatasheetMouse S100A13 Recombinant Protein S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding mo