Human RTN4R Recombinant Protein (RPPB4534)

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RPPB4534

Description

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Product Name:Human RTN4R Recombinant Protein
Product Code:RPPB4534
Size:10µg
Species:Human
Target:RTN4R
Synonyms:Reticulon 4 Receptor, Nogo-66 Receptor, Nogo Receptor,NOGOR, NGR , Reticulon-4 Receptor, UNQ330/PRO526.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RTN4R protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:CPGACVCYNE PKVTTSCPQQ GLQAVPVGIP AASQRIFLHG NRISHVPAASFRACRNLTIL WLHSNVLARI DAAAFTGLAL LEQLDLSDNA QLRSVDPATF HGLGRLHTLH LDRCGLQELGPGLFRGLAAL QYLYLQDNAL QALPDDTFRD LGNLTHLFLH GNRISSVPER AFRGLHSLDR LLLHQNRVAH VHPHAFRDLG RLMTLYLFAN NLSALPTEAL APLRALQYLRLNDNPWVCDC RARPLWAWLQ KFRGSSSEVP CSLPQRLAGR DLKRLAANDL QGCAVATGPY HPIWTGRATDEEPLGLPKCC QPDAADKASV LEPGRPASAG NALKGRVPPG DSPPGNGSGP RHINDSPFGT LPGSAEPPLT AVRPEGSEPP GFPTSGPRRR PGCSRKNRTR SHCRLGQAGSGGGGTGDSEG SLEHHHHHH

Reticulon4 Receptor, also known as RTN4R, plays a role as a receptor for RTN4, OMG andMAG. RTN4R is a glycosylphosphoinositol (GPI)-anchored protein which is a partfrom the Nogo recptor family. RTN4R is expressed mainly in neurons and theiraxons and is regulates axonal regeneration and plasticity in the adult centralnervous system. RTN4R is a potential drug target for treating variousneurological cases such as spinal cord injury, CNS lesions, stroke andAlzheimer's disease.

RTN4R produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 429 amino acids (27-447 a.a.) andhaving a molecular mass of 46.3kDa (Molecular size on SDS-PAGE will appear atapproximately 40-57 kDa). RTN4R is expressed with a 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:RTN4R: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development. Belongs to the Nogo receptor family.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cell surface; growth cone; endoplasmic reticulum; plasma membrane

Molecular Function:protein binding; receptor activity

Biological Process: nerve growth factor receptor signaling pathway; axonogenesis; negative regulation of axonogenesis; regulation of axonogenesis

Disease: Schizophrenia

NCBI Summary:This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BZR6
NCBI GenInfo Identifier:25453267
NCBI Gene ID:65078
NCBI Accession:Q9BZR6.1
UniProt Related Accession:Q9BZR6
Molecular Weight:
NCBI Full Name:Reticulon-4 receptor
NCBI Synonym Full Names:reticulon 4 receptor
NCBI Official Symbol:RTN4R��
NCBI Official Synonym Symbols:NGR; NOGOR��
NCBI Protein Information:reticulon-4 receptor
UniProt Protein Name:Reticulon-4 receptor
UniProt Synonym Protein Names:Nogo receptor; NgR; Nogo-66 receptor
Protein Family:Reticulon-4 receptor
UniProt Gene Name:RTN4R��
UniProt Entry Name:RTN4R_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BZR6
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