Human RTN4IP1 Recombinant Protein (RPPB4535)

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SKU:
RPPB4535
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WWV3

Description

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Product Name:Human RTN4IP1 Recombinant Protein
Product Code:RPPB4535
Size:20µg
Species:Human
Target:RTN4IP1
Synonyms:Reticulon-4-interacting protein 1 mitochondrial, NOGO-interacting mitochondrial protein, RTN4IP1, NIMP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RTN4IP1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.1M�NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSTVMPAWV IDKYGKNEVL RFTQNMMMPI IHYPNEVIVK VHAASVNPID VNMRSGYGAT ALNMKRDPLH VKIKGEEFPL TLGRDVSGVV MECGLDVKYF KPGDEVWAAV PPWKQGTLSE FVVVSGNEVS HKPKSLTHTQ AASLPYVALT AWSAINKVGG LNDKNCTGKR VLILGASGGV GTFAIQVMKA WDAHVTAVCS QDASELVRKL GADDVIDYKS GSVEEQLKSL KPFDFILDNV GGSTETWAPD FLKKWSGATY VTLVTPFLLN MDRLGIADGM LQTGVTVGSK ALKHFWKGVH YRWAFFMASG PCLDDIAELV DAGKIRPVIE QTFPFSKVPE AFLKVERGHA RGKTVINVV

RTN4IP1 is a unique mitochondrial protein that interacts with reticulon 4, which is an effective inhibitor of regeneration ensuing spinal cord injury. The reticulon 4 interaction with mitochondrial proteins may offer insight into the mechanisms for reticulon-induced inhibition of neurite growth.

RTN4IP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 379 amino acids (41-396 a.a.) and having a molecular mass of 41.4kDa. RTN4IP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RTN4IP1: Appears to be a potent inhibitor of regeneration following spinal cord injury. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: MitochondrialChromosomal Location of Human Ortholog: 6q21
UniProt Protein Details:
NCBI Summary:This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, mental retardation, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Code:Q8WWV3
NCBI GenInfo Identifier:76789669
NCBI Gene ID:84816
NCBI Accession:Q8WWV3.2
UniProt Secondary Accession:Q8WWV3,Q8N9B3, Q8WZ66, Q9BRA4
UniProt Related Accession:Q8WWV3
Molecular Weight:24,936 Da
NCBI Full Name:Reticulon-4-interacting protein 1, mitochondrial
NCBI Synonym Full Names:reticulon 4 interacting protein 1
NCBI Official Symbol:RTN4IP1��
NCBI Official Synonym Symbols:NIMP; OPA10��
NCBI Protein Information:reticulon-4-interacting protein 1, mitochondrial
UniProt Protein Name:Reticulon-4-interacting protein 1, mitochondrial
UniProt Synonym Protein Names:NOGO-interacting mitochondrial protein
Protein Family:Reticulon-4-interacting protein
UniProt Gene Name:RTN4IP1��
UniProt Entry Name:RT4I1_HUMAN
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