Human RSU1 Recombinant Protein (RPPB4532)

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SKU:
RPPB4532
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15404

Description

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Product Name:Human RSU1 Recombinant Protein
Product Code:RPPB4532
Size:20µg
Species:Human
Target:RSU1
Synonyms:Ras Suppressor Protein 1, Rsu-1, RSP-1, Ras Suppressor Protein 1 Variant 1, Ras Suppressor Protein 1 Variant 2, Ras Suppressor Protein 1 Variant 3, RSP1, RSU1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RSU1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSKSLKK LVEESREKNQ PEVDMSDRGI SNMLDVNGLF TLSHITQLVL SHNKLTMVPP NIAELKNLEV LNFFNNQIEE LPTQISSLQK LKHLNLGMNR LNTLPRGFGS LPALEVLDLT YNNLSENSLP GNFFYLTTLR ALYLSDNDFE ILPPDIGKLT KLQILSLRDN DLISLPKEIG ELTQLKELHI QGNRLTVLPP ELGNLDLTGQ KQVFKAENNP WVTPIADQFQ LGVSHVFEYI RSETYKYLYG RHMQANPEPP KKNNDKSKKI SRKPLAAKNR

RSU1 is a protein which is involved in the ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as has been established in mouse and human cell line studies. In mouse, RSU1 was originally isolated based on its ability to inhibit v-Ras transformation. RSU1 oossibly has a role in the Ras signal transduction pathway. RSU1 is also capable of suppressing v-Ras transformation in vitro.

RSU1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 300 amino acids (1-277) and having a molecular mass of 33.9 kDa.RSU1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RSU1: a leucine-rich protein that interacts with the IPP (integrin-linked kinase (ILK)/PINCH1/ parvin) focal adhesion complex. Plays a role in Ras signaling pathways. Capable of suppressing v-Ras transformation in vitro
UniProt Protein Details:

Protein type:Cell adhesion

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: focal adhesion; cytosol

Molecular Function:protein binding

Biological Process: Ras protein signal transduction; signal transduction; positive regulation of GTPase activity

NCBI Summary:This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
UniProt Code:Q15404
NCBI GenInfo Identifier:2498866
NCBI Gene ID:6251
NCBI Accession:Q15404.3
UniProt Related Accession:Q15404
Molecular Weight:32 kDa
NCBI Full Name:Ras suppressor protein 1
NCBI Synonym Full Names:Ras suppressor protein 1
NCBI Official Symbol:RSU1��
NCBI Official Synonym Symbols:RSP-1��
NCBI Protein Information:ras suppressor protein 1
UniProt Protein Name:Ras suppressor protein 1
Protein Family:Ras suppressor protein
UniProt Gene Name:RSU1��
UniProt Entry Name:RSU1_HUMAN
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