Human RRAS Recombinant Protein (RPPB4526)
- SKU:
- RPPB4526
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10301
Description
| Product Name: | Human RRAS Recombinant Protein |
| Product Code: | RPPB4526 |
| Size: | 10µg |
| Species: | Human |
| Target: | RRAS |
| Synonyms: | Ras-Related Protein R-Ras, p23, RRAS. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | RRAS Human solution (0.5mg/1ml) containing 20mM Tris-HCl pH-8, 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP SPPSAPRKKG GGCPC |
RRAS belongs to the Ras family which functions in signal transduction pathways. RRAS interacts with RASSF5, NCK1, Bcl-2, ARAF and RALGDS. RRAS binds GTP and GDP, and it has intrinsic GTPase activity. RRAS regulates the organization of the actin cytoskeleton
RRAS Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 235 amino acids (1-215 a.a.) and having a molecular mass of 25.3 kDa. RRAS protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.
| UniProt Protein Function: | RRas: a small G protein of the Ras family. Promotes focal adhesion formation by signaling to FAK and p130(Cas). Promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K. |
| UniProt Protein Details: | Protein type:G protein, monomeric, Ras; Motility/polarity/chemotaxis; G protein, monomeric; G protein Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: focal adhesion; plasma membrane Molecular Function:GDP binding; GTPase activity; protein binding; protein complex binding Biological Process: leukocyte differentiation; positive regulation of angiogenesis; Ras protein signal transduction; regulation of protein kinase B signaling cascade |
| NCBI Summary: | The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P10301 |
| NCBI GenInfo Identifier: | 133486 |
| NCBI Gene ID: | 6237 |
| NCBI Accession: | P10301.1 |
| UniProt Secondary Accession: | P10301,Q6FH12, |
| UniProt Related Accession: | P10301 |
| Molecular Weight: | 23,480 Da |
| NCBI Full Name: | Ras-related protein R-Ras |
| NCBI Synonym Full Names: | related RAS viral (r-ras) oncogene homolog |
| NCBI Official Symbol: | RRAS�� |
| NCBI Protein Information: | ras-related protein R-Ras |
| UniProt Protein Name: | Ras-related protein R-Ras |
| UniProt Synonym Protein Names: | p23 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RRAS�� |
| UniProt Entry Name: | RRAS_HUMAN |
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