Human RRAGC Recombinant Protein (RPPB4524)
- SKU:
- RPPB4524
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HB90
Description
| Product Name: | Human RRAGC Recombinant Protein |
| Product Code: | RPPB4524 |
| Size: | 20µg |
| Species: | Human |
| Target: | RRAGC |
| Synonyms: | Ras-related GTP-binding protein C, Rag C, RagC, GTPase-interacting protein 2, TIB929, RRAGC, GTR2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | RRAGC protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSLQYG AEETPLAGSY GAADSFPKDF GYGVEEEEEE AAAAGGGVGA GAGGGCGPGG ADSSKPRILL MGLRRSGKSS IQKVVFHKMS PNETLFLEST NKIYKDDISN SSFVNFQIWD FPGQMDFFDP TFDYEMIFRG TGALIYVIDA QDDYMEALTR LHITVSKAYK VNPDMNFEVF IHKVDGLSDD HKIETQRDIH QRANDDLADA GLEKLHLSFY LTSIYDHSIF EAFSKVVQKL IPQLPTLENL LNIFISNSGI EKAFLFDVVS KIYIATDSSP VDMQSYELCC DMIDVVIDVS CIYGLKEDGS GSAYDKESMA IIKLNNTTVL YLKEVTKFLA LVCILREESF ERKGLIDYNF HCFRKAIHEV FEVGVTSHRS CGHQTSASSL KALTHNGTPR NAI |
Ras-related GTP binding C (RRAGC) is a monomeric guanine nucleotide-binding protein, or G protein. As a result of binding GTP or GDP, small G proteins act as molecular regulators in various cell processes and signaling pathways. RRAGC regulates the organization of the actin cytoskeleton and has an intrinsic GTPase activity. RRAGC is possibly necessary for the amino acid-induced relocalization of mTORC1 to the lysosomes and its succeeding activation by the GTPase RHEB, which is key step in the activation of the TOR signaling cascade by amino acids.
RRAGC Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 423 amino acids (1-399 a.a) and having a molecular mass of 46.7kDa.RRAGC is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RRAGC: Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p34 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lysosome; nucleus Molecular Function:GDP binding; GTP binding; GTPase activity; magnesium ion binding; protein binding; protein heterodimerization activity Biological Process: apoptosis; cell cycle arrest; cell growth; cellular response to amino acid starvation; gene expression; insulin receptor signaling pathway; macroautophagy; regulation of TOR signaling pathway; RNA splicing; small GTPase mediated signal transduction; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9HB90 |
| NCBI GenInfo Identifier: | 74752776 |
| NCBI Gene ID: | 64121 |
| NCBI Accession: | Q9HB90.1 |
| UniProt Secondary Accession: | Q9HB90,Q9H202, Q9H8Q8, |
| UniProt Related Accession: | Q9HB90 |
| Molecular Weight: | 44,224 Da |
| NCBI Full Name: | Ras-related GTP-binding protein C |
| NCBI Synonym Full Names: | Ras related GTP binding C |
| NCBI Official Symbol: | RRAGC�� |
| NCBI Official Synonym Symbols: | GTR2; RAGC; TIB929�� |
| NCBI Protein Information: | ras-related GTP-binding protein C |
| UniProt Protein Name: | Ras-related GTP-binding protein C |
| UniProt Synonym Protein Names: | GTPase-interacting protein 2; TIB929 |
| Protein Family: | Ras-related GTP-binding protein |
| UniProt Gene Name: | RRAGC�� |
| UniProt Entry Name: | RRAGC_HUMAN |
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