Human RPL22 Recombinant Protein (RPPB4493)
- SKU:
- RPPB4493
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P35268
Description
| Product Name: | Human RPL22 Recombinant Protein |
| Product Code: | RPPB4493 |
| Size: | 10µg |
| Species: | Human |
| Target: | RPL22 |
| Synonyms: | Ribosomal Protein L22, Epstein-Barr-Encoded RNA-Associated Protein, Epstein-Barr Virus Small RNA-Associated Protein, 60S Ribosomal Protein L22, EBER-Associated Protein, EAP, HBP15/L22. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The RPL22 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAPVKKL VVKGGKKKKQ VLKFTLDCTH PVEDGIMDAA NFEQFLQERI KVNGKAGNLG GGVVTIERSK SKITVTSEVP FSKRYLKYLT KKYLKKNNLR DWLRVVANSK ESYELRYFQI NQDEEEEEDE D |
RPL22, a cytoplasmic ribosomal protein, is a member of the L22E family of ribosomal proteins and a component of the 60S subunit. RPL22 binds specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2.
RPL22 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 151 amino acids (1-128) and having a molecular mass of 17.0kDa.RPL22 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RPL22: a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 1p36.31 Cellular Component: focal adhesion; cytoplasm; ribonucleoprotein complex; nucleus; cytosol Molecular Function:heparin binding; protein binding; structural constituent of ribosome; RNA binding Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translational elongation; translation; viral reproduction; mRNA catabolic process, nonsense-mediated decay; translational initiation; alpha-beta T cell differentiation; gene expression; viral transcription; translational termination; viral infectious cycle |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35268 |
| NCBI GenInfo Identifier: | 4506613 |
| NCBI Gene ID: | 6146 |
| NCBI Accession: | NP_000974.1 |
| UniProt Secondary Accession: | P35268,Q6IBD1, B2R495, |
| UniProt Related Accession: | P35268 |
| Molecular Weight: | |
| NCBI Full Name: | 60S ribosomal protein L22 proprotein |
| NCBI Synonym Full Names: | ribosomal protein L22 |
| NCBI Official Symbol: | RPL22�� |
| NCBI Official Synonym Symbols: | EAP; L22; HBP15; HBP15/L22�� |
| NCBI Protein Information: | 60S ribosomal protein L22 |
| UniProt Protein Name: | 60S ribosomal protein L22 |
| UniProt Synonym Protein Names: | EBER-associated protein; EAP; Epstein-Barr virus small RNA-associated protein; Heparin-binding protein HBp15 |
| Protein Family: | 50S ribosomal protein |
| UniProt Gene Name: | RPL22�� |
| UniProt Entry Name: | RL22_HUMAN |
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