Human RPL18A Recombinant Protein (RPPB4492)

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SKU:
RPPB4492
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q02543

Description

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Product Name:Human RPL18A Recombinant Protein
Product Code:RPPB4492
Size:20µg
Species:Human
Target:RPL18A
Synonyms:Ribosomal Protein L18a, Ribosomal Protein L18a-Like Protein, 60S Ribosomal Protein L18a, L18A, RPL18A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The RPL18A solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMKASGTL REYKVVGRCL PTPKCHTPPL YRMRIFAPNH VVAKSRFWYF VSQLKKMKKS SGEIVYCGQV FEKSPLRVKN FGIWLRYDSR SGTHNMYREY RDLTTAGAVT QCYRDMGARH RARAHSIQIM KVEEIAASKC RRPAVKQFHD SKIKFPLPHR VLRRQHKPRF TTKRPNTFF

Ribosomal Protein L18A (RPL18A) is a ribosomal protein which is a component of the 60S subunit, belongs to the L18AE family of ribosomal proteins. RPL18A is located in the cytoplasm. RPL18A is co-transcribed with the U68 snoRNA, which is located in its 3rd intron. The RPL18A protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES).

RPL18A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (1-176) and having a molecular mass of 23.2 kDa.RPL18A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RPL18A: a ribosomal protein of the L18AE family. Located in the cytoplasm. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This protein is a component of the 60S subunit.
UniProt Protein Details:

Protein type:Translation; Ribosomal

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: membrane; cytosol

Molecular Function:structural constituent of ribosome; RNA binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translational elongation; translation; viral reproduction; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; viral infectious cycle; translational termination

NCBI Summary:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
UniProt Code:Q02543
NCBI GenInfo Identifier:730538
NCBI Gene ID:6142
NCBI Accession:Q02543.2
UniProt Related Accession:Q02543
Molecular Weight:
NCBI Full Name:60S ribosomal protein L18a
NCBI Synonym Full Names:ribosomal protein L18a
NCBI Official Symbol:RPL18A��
NCBI Official Synonym Symbols:L18A��
NCBI Protein Information:60S ribosomal protein L18a
UniProt Protein Name:60S ribosomal protein L18a
UniProt Gene Name:RPL18A��
UniProt Entry Name:RL18A_HUMAN
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