Metabolism Recombinant Proteins
Human ROR1 Recombinant Protein (RPES5134)
- SKU:
- RPES5134
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Metabolism
Description
Human ROR1 Recombinant Protein
Receptor tyrosine kinase-like orphan receptor 1 (ROR1); also known as neurotrophic tyrosine kinase; it is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence; a 377 aa extracellular domain (ECD); a 21 aa transmembrane segment; and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart; lung and kidney; but weakly in the CNS. At developmental stage; it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
| Product Name: | Human ROR1 Recombinant Protein (RPES5134) |
| Product Code: | RPES5134 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Inactive tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1 |
| Accession: | Q01973 |
| Sequence: | Gln30-Glu403 |
| Fusion tag: | C-His-Avi |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Biotinylated Recombinant Human ROR1 isproduced by our Mammalian expression system and the target gene encoding Gln30-Glu403 is expressedwith a 6His; Avi tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 44.6 kDa |
| AP Mol Mass: | 55-80 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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