Metabolism Recombinant Proteins
Human ROR1 Recombinant Protein (RPES2091)
- SKU:
- RPES2091
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Metabolism
Description
Human ROR1 Recombinant Protein
CD217; also known as Interleukin-17 receptor A; is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F; it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1; CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK; and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway.
| Product Name: | Human ROR1 Recombinant Protein (RPES2091) |
| Product Code: | RPES2091 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Inactive tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1 |
| Accession: | Q01973 |
| Sequence: | Gln30-Glu403 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human ROR1 is produced by our Mammalian expression system and the target gene encoding Gln30-Glu403 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 68.9 kDa |
| AP Mol Mass: | 90-110 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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