Metabolism Recombinant Proteins

Human ROR1 Recombinant Protein (RPES2091)

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SKU:
RPES2091
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Metabolism

Description

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Human ROR1 Recombinant Protein

CD217; also known as Interleukin-17 receptor A; is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F; it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1; CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK; and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway.

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