Enzymes Recombinant Proteins

Human RNASE7 Recombinant Protein (RPPB2250)

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SKU:
RPPB2250
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9H1E1
Research Area:
Enzymes

Description

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Product Name:Human RNASE7 Recombinant Protein
Product Code:RPPB2250
Size:10µg
Species:Human
Target:RNASE7
Synonyms:Ribonuclease, RNase A Family, 7, Skin-DerivedAntimicrobial Protein 2, RNase 7, SAP-2, EC 3.1.27.5, EC 3.1.27., EC 3.1.27, Ribonuclease 7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RNASE7 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH8.0) and 10% glycerol 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSKPKGMTS SQWFKIQHMQ PSPQACNSAM KNINKHTKRC KDLNTFLHEPFSSVAATCQT PKIACKNGDK NCHQSHGPVS LTMCKLTSGK YPNCRYKEKR QNKSYVVACK PPQKKDSQQFHLVPVHLDRV L

Ribonuclease 7 (RNASE7) is one of the final RNase A superfamily ribonucleases. RNASE7 was isolated from skin-derived stratum corneum. RNASE7 protein demonstrated potent ribonuclease activity and hence may contribute to the well-known ribonuclease activity of human skin. RNASE7 has revealed a broad spectrum antimicrobial activity against many pathogenic microorganisms and extraordinarily potent activity.

RNASE7 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 151 amino acids (29-156 a.a) andhaving a molecular mass of 16.9kDa.RNASE7 is fused to a 23amino acid His-tag at N-terminus & purified by proprietary chromatographictechniques.

UniProt Protein Function:Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium.
NCBI Summary:The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
UniProt Code:Q9H1E1
NCBI GenInfo Identifier:14211885
NCBI Gene ID:84659
NCBI Accession:NP_115961.1
UniProt Secondary Accession:Q9H1E1,P80927, P83685, Q546N3,
UniProt Related Accession:Q9H1E1
Molecular Weight:16.9 kDa (151aa) confirmed by MALDI-TOF
NCBI Full Name:ribonuclease, RNase A family, 7
NCBI Synonym Full Names:ribonuclease A family member 7
NCBI Official Symbol:RNASE7��
NCBI Official Synonym Symbols:RAE1��
NCBI Protein Information:ribonuclease 7
UniProt Protein Name:Ribonuclease 7
UniProt Synonym Protein Names:Skin-derived antimicrobial protein 2; SAP-2
Protein Family:Ribonuclease
UniProt Gene Name:RNASE7��
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