Human RLN3 Recombinant Protein (RPPB4474)
- SKU:
- RPPB4474
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WXF3
Description
| Product Name: | Human RLN3 Recombinant Protein |
| Product Code: | RPPB4474 |
| Size: | 25µg |
| Species: | Human |
| Target: | RLN3 |
| Synonyms: | Relaxin 3, Prorelaxin H3, RXN3, Insl7, ZINS4, H3, Relaxin 3 (H3), Relaxin-3, RLN3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered solution in Acetonitrile and TFA. |
| Solubility: | It is recommended to reconstitute the lyophilized RLN3 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized RLN3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Relaxin-3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | A chain: DVLAGLSSSC CKWGCSKSEI SSLCB chain: RAAPYGVRLCG REFIRAVIFT CGGSRW |
| Biological Activity: | The ED50, as measured by cAMP accumulation in human THP-1 cells, is less than 17.5ng/ml. |
Relaxin-3 (RLN3) belongs to the relaxin family. Relaxins�are endocrine and autocrine/paracrine hormones. Relaxin, which is produced by the ovary, targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. Unlike human Relaxins 1 and 2, Relaxin 3 does not seem to have a role in reproduction; however it is involved in stress response in the brain stem. RLN3 is the only known ligand for the G-protein-coupled receptor GPCR135, titled RXFP3. In addition, RLN3 binds the LGR7 (RXFP1) receptor, however with lower affinity than Relaxin-2. Even though binding of RLN3 to LGR7 increases intracellular cAMP, binding to GPCR135 suppresses cAMP accumulation, indicating coupling to Gi, Go, or Gz by this receptor.
Relaxin-3 Human Recombinant produced in E.Coli is a disulfide-linked heterodimeric, non-glycosylated, polypeptide chain containing 24 amino acids for A chain and 27 amino acids for B chain and having a molecular mass of 2.5kDa for A chain and 3kDa for B chain.The Relaxin-3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RLN3: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). Belongs to the insulin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extracellular region Molecular Function:protein binding; G-protein-coupled receptor binding; hormone activity |
| NCBI Summary: | Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WXF3 |
| NCBI GenInfo Identifier: | 37999891 |
| NCBI Gene ID: | 117579 |
| NCBI Accession: | Q8WXF3.1 |
| UniProt Secondary Accession: | Q8WXF3,Q6UXW5, |
| UniProt Related Accession: | Q8WXF3 |
| Molecular Weight: | 15,451 Da |
| NCBI Full Name: | Relaxin-3 |
| NCBI Synonym Full Names: | relaxin 3 |
| NCBI Official Symbol: | RLN3�� |
| NCBI Official Synonym Symbols: | H3; RXN3; ZINS4; insl7�� |
| NCBI Protein Information: | relaxin-3; prorelaxin H3; insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7 |
| UniProt Protein Name: | Relaxin-3 |
| UniProt Synonym Protein Names: | Insulin-like peptide INSL7; Insulin-like peptide 7; Prorelaxin H3Cleaved into the following 2 chains:Relaxin-3 B chain; Relaxin-3 A chain |
| Protein Family: | Relaxin |
| UniProt Gene Name: | RLN3�� |
| UniProt Entry Name: | REL3_HUMAN |
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