Human RLN2 Recombinant Protein (RPPB4472)

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SKU:
RPPB4472
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P04090

Description

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Product Name:Human RLN2 Recombinant Protein
Product Code:RPPB4472
Size:25µg
Species:Human
Target:RLN2
Synonyms:Prorelaxin H2, RLN2, H2, RLXH2, H2-RLX, bA12D24.1.1, bA12D24.1.2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RLN2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSDSWMEEV IKLCGRELVR AQIAICGMST WSKRSLSQED APQTPRPVAE IVPSFINKDT ETINMMSEFV ANLPQELKLT LSEMQPALPQ LQQHVPVLKD SSLLFEEFKK LIRNRQSEAA DSSPSELKYL GLDTHSRKKR QLYSALANKC CHVGCTKRSL ARFC

Prorelaxin H2 (RLN2) is a member of a family which is produced by the ovary, targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may also have other roles in boosting sperm motility, regulating blood pressure, controlling heart rate and releasing vasopressin. RLN2 is a peptide hormone linked to several therapeutically relevant physiological effects, including regulation of collagen metabolism and multiple vascular control pathways. The active form of the RLN2 protein consists of an A chain and a B chain linked by disulfide bonds.

RLN2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids (25-185 a.a) and having a molecular mass of 20.7kDa.RLN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RLN2: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular region

Molecular Function:hormone activity

Biological Process: female pregnancy

NCBI Summary:Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Code:P04090
NCBI GenInfo Identifier:132281
NCBI Gene ID:6019
NCBI Accession:P04090.1
UniProt Secondary Accession:P04090,Q99936, Q9UCX3, Q9UQJ2, A0AVM0,
UniProt Related Accession:P04090
Molecular Weight:185
NCBI Full Name:Prorelaxin H2
NCBI Synonym Full Names:relaxin 2
NCBI Official Symbol:RLN2��
NCBI Official Synonym Symbols:H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2��
NCBI Protein Information:prorelaxin H2; H2-preprorelaxin; relaxin, ovarian, of pregnancy
UniProt Protein Name:Prorelaxin H2
Protein Family:Prorelaxin
UniProt Gene Name:RLN2��
UniProt Entry Name:REL2_HUMAN
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