Human RHOD Recombinant Protein (RPPB4461)

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SKU:
RPPB4461
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O00212

Description

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Product Name:Human RHOD Recombinant Protein
Product Code:RPPB4461
Size:5µg
Species:Human
Target:RHOD
Synonyms:Rho-related GTP-binding protein RhoD, Rho-related protein HP1, RhoHP1, RHOD, ARHD, Rho, RHOM.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RHOD solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 50% glycerol, 200mM NaCl, 2mM EDTA and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MVKVVLVGDG GCGKTSLLMV FADGAFPESY TPTVFERYMV NLQVKGKPVH LHIWDTAGQD DYDRLRPLFY PDASVLLLCF DVTSPNSFDN IFNRWYPEVN HFCKKVPIIV VGCKTDLRKD KSLVNKLRRN GLEPVTYHRG QEMARSVGAV AYLECSARLHDNVHAVFQEA AEVALSSRGR NFWRRITQGF C

Rho-related GTP-binding protein (RhoD) is a member of the small GTPase superfamily. The small GTPase Rho D promotes the rearrangement of the actin cytoskeleton and cell surface and also regulates endosome motility and distribution.

RHOD produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (18-207 a.a.) and having a molecular mass of 23.8kDa.RHOD is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RHOD: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton. Belongs to the small GTPase superfamily. Rho family.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric, Rho; G protein, monomeric; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: early endosome; plasma membrane; cytosol

Molecular Function:GTPase activity; GTP binding; protein kinase binding

Biological Process: focal adhesion formation; lamellipodium biogenesis; actin filament bundle formation; regulation of small GTPase mediated signal transduction; positive regulation of cell adhesion; metabolic process; small GTPase mediated signal transduction; regulation of focal adhesion formation; Rho protein signal transduction; protein targeting; positive regulation of cell migration

NCBI Summary:Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:O00212
NCBI GenInfo Identifier:254763327
NCBI Gene ID:29984
NCBI Accession:O00212.2
UniProt Related Accession:O00212
Molecular Weight:210
NCBI Full Name:Rho-related GTP-binding protein RhoD
NCBI Synonym Full Names:ras homolog family member D
NCBI Official Symbol:RHOD��
NCBI Official Synonym Symbols:Rho; ARHD; RHOM; RHOHP1��
NCBI Protein Information:rho-related GTP-binding protein RhoD; ras homolog D; Rho-related protein HP1; ras homolog gene family, member A; ras homolog gene family, member D
UniProt Protein Name:Rho-related GTP-binding protein RhoD
UniProt Synonym Protein Names:Rho-related protein HP1; RhoHP1
Protein Family:Rhodopsin
UniProt Gene Name:RHOD��
UniProt Entry Name:RHOD_HUMAN
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