Human RHOC Recombinant Protein (RPPB4460)
- SKU:
- RPPB4460
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P08134
Description
| Product Name: | Human RHOC Recombinant Protein |
| Product Code: | RPPB4460 |
| Size: | 10µg |
| Species: | Human |
| Target: | RHOC |
| Synonyms: | ARH9, ARHC, H9, RHOH9, RAS-related homolog 9, Rho cDNA clone 9, Rho-related GTP-binding protein RhoC, ARH9, MGC1448, MGC61427, RHOC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | RHOC Human 0.5mg/ml solution containing 20mM Tris-HCl pH-8, 0.1M NaCl, 1mM DTT & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKRRRGC |
RHOC is a small signaling G protein/GTPase which is part of the Rac subfamily of the family Rho family of GTPases. RHOC rotats between inactive GDP-bound and active GTP-bound states and has a role as a molecular switch in signal transduction cascades. RHOC promotes reorganization of the actin cytoskeleton and regulates cell shape, attachment, and motility.
RHOC Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190 a.a.) and having a molecular mass of 23.8 kDa. The RHOC is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RHOC: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. |
| UniProt Protein Details: | Protein type:G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: cleavage furrow; cytosol; plasma membrane Molecular Function:protein binding; signal transducer activity Biological Process: apical junction assembly; cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; regulation of small GTPase mediated signal transduction |
| NCBI Summary: | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08134 |
| NCBI GenInfo Identifier: | 132543 |
| NCBI Gene ID: | 389 |
| NCBI Accession: | P08134.1 |
| UniProt Secondary Accession: | P08134,Q6ICN3, B3KSW1, |
| UniProt Related Accession: | P08134 |
| Molecular Weight: | 22,006 Da |
| NCBI Full Name: | Rho-related GTP-binding protein RhoC |
| NCBI Synonym Full Names: | ras homolog family member C |
| NCBI Official Symbol: | RHOC�� |
| NCBI Official Synonym Symbols: | H9; ARH9; ARHC; RHOH9�� |
| NCBI Protein Information: | rho-related GTP-binding protein RhoC |
| UniProt Protein Name: | Rho-related GTP-binding protein RhoC |
| UniProt Synonym Protein Names: | Rho cDNA clone 9; h9 |
| Protein Family: | Rho-related GTP-binding protein |
| UniProt Gene Name: | RHOC�� |
| UniProt Entry Name: | RHOC_HUMAN |
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