Human RHOB Recombinant Protein (RPPB4459)

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SKU:
RPPB4459
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62745

Description

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Product Name:Human RHOB Recombinant Protein
Product Code:RPPB4459
Size:10µg
Species:Human
Target:RHOB
Synonyms:Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6, RHOB, ARH6, ARHB, RHOH6, MST081, MSTP081.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RHOB protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 20% glycerol and 0.2mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ KRYGSQNGCI NCC

Rho-related GTP-binding protein RhoB (RhoB) belongs to the Rho GTP-binding protein family. RhoB facilitates apoptosis in neoplastically transformed cells after DNA damage. RhoB has a negative role in tumorigenesis since deletion causes tumor formation.

RHOB produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-193 a.a.) and having a molecular mass of 23.9kDa (Molecular weight on SDS-PAGE will appear higher).RHOB is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RHOB: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.
UniProt Protein Details:

Protein type:G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 2p24.1

Cellular Component: cleavage furrow; cytosol; endosome membrane; focal adhesion; nucleus; plasma membrane

Molecular Function:GTP binding; GTPase activity; protein binding

Biological Process: apoptosis; cell adhesion; cytokinesis; endosome to lysosome transport; negative regulation of cell cycle; negative regulation of cell migration; platelet activation; positive regulation of angiogenesis; positive regulation of apoptosis; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction

UniProt Code:P62745
NCBI GenInfo Identifier:51338601
NCBI Gene ID:388
NCBI Accession:P62745.1
UniProt Secondary Accession:P62745,P01121, Q5U0H6, Q7RTN5, Q7RTR9, Q9CUV7, B2R692
UniProt Related Accession:P62745
Molecular Weight:22kDa
NCBI Full Name:Rho-related GTP-binding protein RhoB
NCBI Synonym Full Names:ras homolog family member B
NCBI Official Symbol:RHOB��
NCBI Official Synonym Symbols:ARH6; ARHB; RHOH6; MST081; MSTP081��
NCBI Protein Information:rho-related GTP-binding protein RhoB
UniProt Protein Name:Rho-related GTP-binding protein RhoB
UniProt Synonym Protein Names:Rho cDNA clone 6; h6
Protein Family:Rho-related GTP-binding protein
UniProt Gene Name:RHOB��
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