Human RGS5 Recombinant Protein (RPPB4456)

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SKU:
RPPB4456
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O15539

Description

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Product Name:Human RGS5 Recombinant Protein
Product Code:RPPB4456
Size:25µg
Species:Human
Target:RGS5
Synonyms:Regulator of G-protein signaling 5, RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RGS5 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMCKGLA ALPHSCLERA KEIKIKLGIL LQKPDSVGDL VIPYNEKPEK PAKTQKTSLD EALQWRDSLD KLLQNNYGLA SFKSFLKSEF SEENLEFWIA CEDYKKIKSP AKMAEKAKQI YEEFIQTEAP KEVNIDHFTK DITMKNLVEP SLSSFDMAQK RIHALMEKDS LPRFVRSEFY QELIK

Regulator of G-protein signaling 5 (RGS5) binds directly to activated G alpha subunits and act as GTPase-activating proteins (GAPs) in order to weaken and/or modulate hormone and neurotransmitter receptor-initiated signaling by both G alpha-GTP and G beta gamma. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, consequently rendering it a candidate gene involved in capillary growth, angiogenesis, and also possibly the pathophysiology of stroke.

RGS5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 205 amino acids (1-181 a.a.) and having a molecular mass of 23.5kDa.RGS5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RGS5: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cytoplasm; plasma membrane

Molecular Function:GTPase activator activity

Biological Process: regulation of G-protein coupled receptor protein signaling pathway

Disease: Hypertension, Essential

NCBI Summary:This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
UniProt Code:O15539
NCBI GenInfo Identifier:3914625
NCBI Gene ID:8490
NCBI Accession:O15539.1
UniProt Secondary Accession:O15539,Q53XA9, Q599J0, E9PMP5,
UniProt Related Accession:O15539
Molecular Weight:21,402 Da
NCBI Full Name:Regulator of G-protein signaling 5
NCBI Synonym Full Names:regulator of G-protein signaling 5
NCBI Official Symbol:RGS5��
NCBI Official Synonym Symbols:MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129��
NCBI Protein Information:regulator of G-protein signaling 5
UniProt Protein Name:Regulator of G-protein signaling 5
Protein Family:Regulator of G-protein signaling
UniProt Gene Name:RGS5��
UniProt Entry Name:RGS5_HUMAN
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