Human RGS5 Recombinant Protein (RPPB4456)
- SKU:
- RPPB4456
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O15539
Description
| Product Name: | Human RGS5 Recombinant Protein |
| Product Code: | RPPB4456 |
| Size: | 25µg |
| Species: | Human |
| Target: | RGS5 |
| Synonyms: | Regulator of G-protein signaling 5, RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RGS5 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMCKGLA ALPHSCLERA KEIKIKLGIL LQKPDSVGDL VIPYNEKPEK PAKTQKTSLD EALQWRDSLD KLLQNNYGLA SFKSFLKSEF SEENLEFWIA CEDYKKIKSP AKMAEKAKQI YEEFIQTEAP KEVNIDHFTK DITMKNLVEP SLSSFDMAQK RIHALMEKDS LPRFVRSEFY QELIK |
Regulator of G-protein signaling 5 (RGS5) binds directly to activated G alpha subunits and act as GTPase-activating proteins (GAPs) in order to weaken and/or modulate hormone and neurotransmitter receptor-initiated signaling by both G alpha-GTP and G beta gamma. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, consequently rendering it a candidate gene involved in capillary growth, angiogenesis, and also possibly the pathophysiology of stroke.
RGS5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 205 amino acids (1-181 a.a.) and having a molecular mass of 23.5kDa.RGS5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RGS5: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: cytoplasm; plasma membrane Molecular Function:GTPase activator activity Biological Process: regulation of G-protein coupled receptor protein signaling pathway Disease: Hypertension, Essential |
| NCBI Summary: | This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011] |
| UniProt Code: | O15539 |
| NCBI GenInfo Identifier: | 3914625 |
| NCBI Gene ID: | 8490 |
| NCBI Accession: | O15539.1 |
| UniProt Secondary Accession: | O15539,Q53XA9, Q599J0, E9PMP5, |
| UniProt Related Accession: | O15539 |
| Molecular Weight: | 21,402 Da |
| NCBI Full Name: | Regulator of G-protein signaling 5 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 5 |
| NCBI Official Symbol: | RGS5�� |
| NCBI Official Synonym Symbols: | MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129�� |
| NCBI Protein Information: | regulator of G-protein signaling 5 |
| UniProt Protein Name: | Regulator of G-protein signaling 5 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS5�� |
| UniProt Entry Name: | RGS5_HUMAN |
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