Human RGS2 Recombinant Protein (RPPB4453)
- SKU:
- RPPB4453
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P41220
Description
| Product Name: | Human RGS2 Recombinant Protein |
| Product Code: | RPPB4453 |
| Size: | 5µg |
| Species: | Human |
| Target: | RGS2 |
| Synonyms: | Regulator of G-protein Signaling 2 24kDa, G0S8, G0/G1 switch regulatory protein 8, Cell growth-inhibiting gene 31 protein, RGS2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The RGS2 protein solution (0.25mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 2mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T |
RGS2 belongs to the RGS family which are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. RGS2 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits and as a result driving them into their inactive GDP-bound form.
RGS2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 231 amino acids (1-211a.a.) and having a molecular mass of 26.5 kDa. RGS2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Nucleolus; GAPs, misc.; GAPs Chromosomal Location of Human Ortholog: 1q31 Cellular Component: internal side of plasma membrane; neuron projection; mitochondrion; cytoplasm; plasma membrane; nucleolus; cytosol Molecular Function:calmodulin binding; protein binding; beta-tubulin binding; GTPase activator activity Biological Process: regulation of translation; negative regulation of MAP kinase activity; relaxation of vascular smooth muscle; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of microtubule polymerization; brown fat cell differentiation; spermatogenesis; cell cycle; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity |
| NCBI Summary: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009] |
| UniProt Code: | P41220 |
| NCBI GenInfo Identifier: | 729545 |
| NCBI Gene ID: | 5997 |
| NCBI Accession: | P41220.1 |
| UniProt Secondary Accession: | P41220,Q6I9U5, |
| UniProt Related Accession: | P41220 |
| Molecular Weight: | 211 |
| NCBI Full Name: | Regulator of G-protein signaling 2 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 2 |
| NCBI Official Symbol: | RGS2�� |
| NCBI Official Synonym Symbols: | G0S8�� |
| NCBI Protein Information: | regulator of G-protein signaling 2; G0/G1 switch regulatory protein 8; cell growth-inhibiting protein 31; G0 to G1 switch regulatory 8, 24kD; cell growth-inhibiting gene 31 protein; regulator of G-protein signaling 2, 24kDa |
| UniProt Protein Name: | Regulator of G-protein signaling 2 |
| UniProt Synonym Protein Names: | Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS2�� |
| UniProt Entry Name: | RGS2_HUMAN |
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