Human RGS10 Recombinant Protein (RPPB4448)
- SKU:
- RPPB4448
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43665
Description
| Product Name: | Human RGS10 Recombinant Protein |
| Product Code: | RPPB4448 |
| Size: | 25µg |
| Species: | Human |
| Target: | RGS10 |
| Synonyms: | Regulator Of G-Protein Signaling 10, RGS10. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RGS10 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMFNRAV SRLSRKRPPS DIHDSDGSSS SSHQSLKSTA KWAASLENLL EDPEGVKRFR EFLKKEFSEE NVLFWLACED FKKMQDKTQM QEKAKEIYMT FLSSKASSQV NVEGQSRLNE KILEEPHPLM FQKLQDQIFN LMKYDSYSRF LKSDLFLKHK RTEEEEEDLP DAQTAAKRAS RIYNT |
RGS10 is a member of the RGS family that regulate molecules which perform as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins can disengage G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. The nucleus localized RGS10 is associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but is unable to cooperate with the structurally and functionally distinct G-alpha subunits.
RGS10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 205 amino acids (1-181) and having a molecular mass of 23.7 kDa.The RGS10 is fused to a 24 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RGS10: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 10q25 Cellular Component: cell soma; cytoplasm; dendritic spine; plasma membrane; nerve terminal; nucleus Molecular Function:GTPase activator activity Biological Process: positive regulation of GTPase activity |
| NCBI Summary: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43665 |
| NCBI GenInfo Identifier: | 52694755 |
| NCBI Gene ID: | 6001 |
| NCBI Accession: | NP_001005339.1 |
| UniProt Secondary Accession: | O43665,Q6IAZ6, Q96GN0, A8K408, B1AMR8, |
| UniProt Related Accession: | O43665 |
| Molecular Weight: | 20 KD |
| NCBI Full Name: | regulator of G-protein signaling 10 isoform a |
| NCBI Synonym Full Names: | regulator of G-protein signaling 10 |
| NCBI Official Symbol: | RGS10�� |
| NCBI Protein Information: | regulator of G-protein signaling 10; regulator of G-protein signalling 10 |
| UniProt Protein Name: | Regulator of G-protein signaling 10 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS10�� |
| UniProt Entry Name: | RGS10_HUMAN |
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