Description
| Product Name: | Human REXO2 Recombinant Protein |
| Product Code: | RPPB2244 |
| Size: | 20µg |
| Species: | Human |
| Target: | REXO2 |
| Synonyms: | REX2, RNA exonuclease 2 homolog (S. cerevisiae), CGI-114, RFN, SFN, Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, Small fragment nuclease,REXO2, SMFN. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The REXO2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVREGGAA MAAGESMAQR MVWVDLEMTG LDIEKDQIIE MACLITDSDL NILAEGPNLI IKQPDELLDS MSDWCKEHHG KSGLTKAVKE STITLQQAEY EFLSFVRQQT PPGLCPLAGN SVHEDKKFLD KYMPQFMKHL HYRIIDVSTV KELCRRWYPE EYEFAPKKAA SHRALDDISE SIKELQFYRN NIFKKKIDEK KRKIIENGEN EKTVS |
EXO2 is a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. RNA Exonuclease 2 (REXO2) takes part in DNA repair, replication, and recombination, and in RNA processing and degradation. EXO2 is involved in resistance of human cells to UV-C-induced cell death via its part in the DNA repair process.
REXO2 Human Recombinant produced in E. coli is a single polypeptide chain containing 235 amino acids (26-237) and having a molecular mass of 26.8kDa. REXO2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | REXO2: a 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily |
| UniProt Protein Details: | Protein type:EC 3.1.-.-; Hydrolase Chromosomal Location of Human Ortholog: 11q23.2 Cellular Component: focal adhesion; mitochondrion; nucleolus; nucleus Molecular Function:3'-5' exonuclease activity; 3'-5'-exoribonuclease activity Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleotide metabolic process |
| NCBI Summary: | This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9Y3B8 |
| NCBI GenInfo Identifier: | 116242694 |
| NCBI Gene ID: | 25996 |
| NCBI Accession: | Q9Y3B8.3 |
| UniProt Secondary Accession: | Q9Y3B8,Q32Q18, Q53FT1, Q6FIC6, Q9UFY7, B2R532, |
| UniProt Related Accession: | Q9Y3B8 |
| Molecular Weight: | 23,754 Da |
| NCBI Full Name: | Oligoribonuclease, mitochondrial |
| NCBI Synonym Full Names: | RNA exonuclease 2 |
| NCBI Official Symbol: | REXO2�� |
| NCBI Official Synonym Symbols: | RFN; SFN; REX2; CGI-114�� |
| NCBI Protein Information: | oligoribonuclease, mitochondrial |
| UniProt Protein Name: | Oligoribonuclease, mitochondrial |
| UniProt Synonym Protein Names: | RNA exonuclease 2 homolog; Small fragment nuclease |
| UniProt Gene Name: | REXO2�� |
| UniProt Entry Name: | ORN_HUMAN |
