Enzymes Recombinant Proteins
Human REXO1 Recombinant Protein (RPPB2243)
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- SKU:
- RPPB2243
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8N1G1
- Research Area:
- Enzymes
Description
| Product Name: | Human REXO1 Recombinant Protein |
| Product Code: | RPPB2243 |
| Size: | 20µg |
| Species: | Human |
| Target: | REXO1 |
| Synonyms: | RNA exonuclease 1 homolog, Elongin-A-binding protein 1, EloA-BP1, Transcription elongation factor B polypeptide 3-binding protein 1, REXO1, ELOABP1, KIAA1138, TCEB3BP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The REXO1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSIYAL DCEMSYTTYG LELTRVTVVD TDVHVVYDTF VKPDNEIVDY NTRFSGVTEA DLADTSVTLR DVQAVLLSMF SADTILIGHS LESDLLALKV IHSTVVDTSV LFPHRLGLPY KRSLRNLMAD YLRQIIQDNV DGHSSSEDAG ACMHLVIWKV REDAKTKR |
REXO1 is an exonuclease domain-containing protein which binds to Elongin. The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. REXO1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. REXO1 is a putative stem cell marker and is highly expressed in embryonic and adult stem cells.
REXO1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (1060-1221a.a) and having a molecular mass of 22.3kDa. REXO1 is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | REXO1: Seems to have no detectable effect on transcription elongation in vitro. Belongs to the REXO1/REXO3 family.Protein type: Hydrolase; EC 3.1.-.-Chromosomal Location of Human Ortholog: 19p13.3Cellular Component: nucleoplasmMolecular Function: nucleic acid binding; exonuclease activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N1G1 |
| NCBI GenInfo Identifier: | 145199237 |
| NCBI Gene ID: | 57455 |
| NCBI Accession: | NP_065746.3 |
| UniProt Secondary Accession: | Q8N1G1,Q9ULT2 |
| UniProt Related Accession: | Q8N1G1 |
| Molecular Weight: | 131,510 Da |
| NCBI Full Name: | RNA exonuclease 1 homolog |
| NCBI Synonym Full Names: | REX1, RNA exonuclease 1 homolog |
| NCBI Official Symbol: | REXO1�� |
| NCBI Official Synonym Symbols: | REX1; ELOABP1; EloA-BP1; TCEB3BP1�� |
| NCBI Protein Information: | RNA exonuclease 1 homolog |
| UniProt Protein Name: | RNA exonuclease 1 homolog |
| UniProt Synonym Protein Names: | Elongin-A-binding protein 1; EloA-BP1; Transcription elongation factor B polypeptide 3-binding protein 1 |
| Protein Family: | Redox-sensing transcriptional repressor |
| UniProt Gene Name: | REXO1�� |
| UniProt Entry Name: | REXO1_HUMAN |
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