Human RERG Recombinant Protein (RPPB4444)

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SKU:
RPPB4444
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96A58

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human RERG Recombinant Protein
Product Code:RPPB4444
Size:10µg
Species:Human
Target:RERG
Synonyms:Ras-related and estrogen-regulated growth inhibitor, RERG, MGC15754.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RERG solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS

RERG is a 199 amino acid protein which localizes in the cytoplasm and is a member of the Ras subfamily of small GTPases. RERG is expressed in the pancreas, liver, skin, lung, brain, kidney and heart tissue. RERG is a vital mediator of diverse cell signaling pathways, including those leading to cell proliferation, cytoskeletal organization and secretion.

RERG Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�219 amino acids (1-199 a.a.) and having a molecular mass of 24.7kDa (Molecular size on SDS-PAGE will appear higher). The RERG is purified by proprietary chromatographic techniques.

UniProt Protein Function:RERG: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric; G protein; G protein, monomeric, RasChromosomal Location of Human Ortholog: 12p12.3Cellular Component: membrane; cytosol; nucleusMolecular Function: GTPase activity; GDP binding; GTP binding; estrogen receptor bindingBiological Process: negative regulation of cell proliferation; metabolic process; small GTPase mediated signal transduction; response to hormone stimulus; negative regulation of cell growth
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q96A58
NCBI GenInfo Identifier:74731090
NCBI Gene ID:
NCBI Accession:Q96A58.1
UniProt Secondary Accession:Q96A58
UniProt Related Accession:Q96A58
Molecular Weight:
NCBI Full Name:Ras-related and estrogen-regulated growth inhibitor
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Ras-related and estrogen-regulated growth inhibitor
UniProt Synonym Protein Names:
Protein Family:Ras-related and estrogen-regulated growth inhibitor
UniProt Gene Name:RERG��
UniProt Entry Name:RERG_HUMAN
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