Human RERG Recombinant Protein (RPPB4444)
- SKU:
- RPPB4444
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96A58
Description
| Product Name: | Human RERG Recombinant Protein |
| Product Code: | RPPB4444 |
| Size: | 10µg |
| Species: | Human |
| Target: | RERG |
| Synonyms: | Ras-related and estrogen-regulated growth inhibitor, RERG, MGC15754. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RERG solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS |
RERG is a 199 amino acid protein which localizes in the cytoplasm and is a member of the Ras subfamily of small GTPases. RERG is expressed in the pancreas, liver, skin, lung, brain, kidney and heart tissue. RERG is a vital mediator of diverse cell signaling pathways, including those leading to cell proliferation, cytoskeletal organization and secretion.
RERG Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�219 amino acids (1-199 a.a.) and having a molecular mass of 24.7kDa (Molecular size on SDS-PAGE will appear higher). The RERG is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RERG: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric; G protein; G protein, monomeric, RasChromosomal Location of Human Ortholog: 12p12.3Cellular Component: membrane; cytosol; nucleusMolecular Function: GTPase activity; GDP binding; GTP binding; estrogen receptor bindingBiological Process: negative regulation of cell proliferation; metabolic process; small GTPase mediated signal transduction; response to hormone stimulus; negative regulation of cell growth |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96A58 |
| NCBI GenInfo Identifier: | 74731090 |
| NCBI Gene ID: | |
| NCBI Accession: | Q96A58.1 |
| UniProt Secondary Accession: | Q96A58 |
| UniProt Related Accession: | Q96A58 |
| Molecular Weight: | |
| NCBI Full Name: | Ras-related and estrogen-regulated growth inhibitor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Ras-related and estrogen-regulated growth inhibitor |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ras-related and estrogen-regulated growth inhibitor |
| UniProt Gene Name: | RERG�� |
| UniProt Entry Name: | RERG_HUMAN |
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