Cytokines Recombinant Proteins

Human RELM b Recombinant Protein (RPPB0922)

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SKU:
RPPB0922
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BQ08
Research Area:
Cytokines

Description

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Product Name:Human RELM b Recombinant Protein
Product Code:RPPB0922
Size:25µg
Species:Human
Target:RELM b
Synonyms:Resistin-like beta, RELM beta, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein, RELM-b, XCP2, HXCP2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:RELM-b was lyophilized from a solution containing 0.1% Trifluoroacetic Acid (TFA).
Solubility:It is recommended to reconstitute the lyophilized RELM-b in sterile 0.1% TFA not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized RELM-b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution RELM-b Human Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MQCSLDSVMD KKIKDVLNSL EYSPSPISKK LSCASVKSQG RPSSCPAGMA VTGCACGYGC GSWDVQLETT CHCQCSVVDW TTARCCHLT

RELM-beta (Resistin-Like Molecule-beta) is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin (also called FIZZ3), RELM-alfa (FIZZ1), RELM-beta (FIZZ2) and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents.RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant.The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice.

RELM-b Human Recombinant produced in E.Coli is a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 19kDa. RELM-b is purified by proprietary chromatographic techniques.

UniProt Protein Function:resistin-like beta: Probable hormone. Belongs to the resistin/FIZZ family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 3q13.1

Cellular Component: cellular_component; extracellular region

Molecular Function:hormone activity; molecular_function

Biological Process: cell proliferation

UniProt Code:Q9BQ08
NCBI GenInfo Identifier:14211897
NCBI Gene ID:84666
NCBI Accession:NP_115968.1
UniProt Secondary Accession:Q9BQ08,Q14D27,
UniProt Related Accession:Q9BQ08
Molecular Weight:11,730 Da
NCBI Full Name:resistin-like beta
NCBI Synonym Full Names:resistin like beta
NCBI Official Symbol:RETNLB��
NCBI Official Synonym Symbols:XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta��
NCBI Protein Information:resistin-like beta; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2; colon and small intestine-specific cysteine-rich protein; colon carcinoma-related gene protein; cysteine-rich secreted A12-alpha-like protein 1; cyste
UniProt Protein Name:Resistin-like beta
UniProt Synonym Protein Names:Colon and small intestine-specific cysteine-rich protein; Colon carcinoma-related gene protein; Cysteine-rich secreted protein A12-alpha-like 1; Cysteine-rich secreted protein FIZZ2; RELMbeta
Protein Family:Resistin
UniProt Gene Name:RETNLB��
UniProt Entry Name:RETNB_HUMAN
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