Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate. It is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Expression of the Reg4 in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution.
Product Name:
Human REG4/RELP Recombinant Protein (RPES3117)
Product Code:
RPES3117
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
Regenerating islet-derived protein 4, Gastrointestinal secretory protein, REG-like protein, Regenerating islet-derived protein IV, GISP, RELP, REG4,GISP,REG-IV
Accession:
Q9BYZ8-1
Sequence:
Asp23-Pro158
Fusion tag:
N-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human REG4 (Q9BYZ8-1) (Asp23-Pro158) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
44.3 kDa
AP Mol Mass:
45 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetHuman REG4/RELP Recombinant Protein REG4 is a secreted contains one C-type lectin domain, high expressed in the gastrointestinal tract, including jejunum, ileum, appendi
system_update_altDatasheetMouse REG4/RELP Recombinant Protein Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family b
system_update_altDatasheetRat REG4 Recombinant Protein Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belongin
system_update_altDatasheetRat REG4 Recombinant Protein Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belongin
Rat REG4 Recombinant Protein (His Tag) (RPES5837)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
Mouse REG4 Recombinant Protein (His Tag) (RPES5716)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
