Human RCN2 Recombinant Protein (RPPB4430)

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RPPB4430

Description

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Product Name:Human RCN2 Recombinant Protein
Product Code:RPPB4430
Size:10µg
Species:Human
Target:RCN2
Synonyms:Reticulocalbin-2, Calcium-binding protein ERC-55, E6-binding protein, 6BP, RCN2, ERC55, E6BP, ERC-55, TCBP49.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RCN2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEELHYPLGE RRSDYDREAL LGVQEDVDEY VKLGHEEQQK RLQAIIKKID LDSDGFLTES ELSSWIQMSF KHYAMQEAKQ QFVEYDKNSD DTVTWDEYNI QMYDRVIDFD ENTALDDAEE ESFRKLHLKD KKRFEKANQD SGPGLSLEEF IAFEHPEEVDYMTEFVIQEA LEEHDKNGDG FVSLEEFLGD YRWDPTANED PEWILVEKDR FVNDYDKDND GRLDPQELLP WVVPNNQGIA QEEALHLIDE MDLNGDKKLS EEEILENPDL FLTSEATDYG RQLHDDYFYH DEL

Reticulocalbin-2 (RCN2) is a member of the CREC protein family. RCN2 is a calcium-binding protein found in the lumen of the ER. RCN2 contains 6 conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand.

RCN2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 313 amino acids (26-317 a.a.) and having a molecular mass of 36.8kDa (Molecular weight on SDS-PAGE will appear higher).RCN2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RCN2: Not known. Binds calcium. Belongs to the CREC family.
UniProt Protein Details:

Protein type:Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum; nucleolus

Molecular Function:protein binding; calcium ion binding

NCBI Summary:The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
UniProt Code:Q14257
NCBI GenInfo Identifier:2493460
NCBI Gene ID:5955
NCBI Accession:Q14257.1
UniProt Related Accession:Q14257
Molecular Weight:
NCBI Full Name:Reticulocalbin-2
NCBI Synonym Full Names:reticulocalbin 2
NCBI Official Symbol:RCN2��
NCBI Official Synonym Symbols:E6BP; ERC55; ERC-55; TCBP49��
NCBI Protein Information:reticulocalbin-2
UniProt Protein Name:Reticulocalbin-2
UniProt Synonym Protein Names:Calcium-binding protein ERC-55; E6-binding protein; E6BP
Protein Family:Reticulocalbin
UniProt Gene Name:RCN2��
UniProt Entry Name:RCN2_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q14257
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