Human RCN1 Recombinant Protein (RPPB4429)
- SKU:
- RPPB4429
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15293
Description
| Product Name: | Human RCN1 Recombinant Protein |
| Product Code: | RPPB4429 |
| Size: | 10µg |
| Species: | Human |
| Target: | RCN1 |
| Synonyms: | PIG20, RCAL, RCN. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | 1mg/ml solution containing 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEK PTVRKERVVR PDSELGERPP EDNQSFQYDH EAFLGKEDSK TFDQLTPDES KERLGKIVDR IDNDGDGFVT TEELKTWIKR VQKRYIFDNV AKVWKDYDRD KDDKISWEEY KQATYGYYLG NPAEFHDSSD HHTFKKMLPR DERRFKAADL NGDLTATREE FTAFLHPEEF EHMKEIVVLE TLEDIDKNGD GFVDQDEYIA DMFSHEENGP EPDWVLSERE QFNEFRDLNK DGKLDKDEIR HWILPQDYDH AQAEARHLVY ESDKNKDEKL TKEEILENWN MFVGSQATNY GEDLTKNHDE L |
RCN1 is a calcium-binding protein which binds calcium and controls calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. RCN1 withholds six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in relation to mouse reticulocalbin, is consistent with a biochemical function further to that of calcium binding. In human endothelial and prostate cancer cell lines RCN1 protein is localized to the plasma membrane.
RCN1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 341 amino acids (30-331 a.a.) and having a molecular mass of 40.4kDa (real molecular weight on SDS-PAGE will be shift up). The RCN1 is fused to 39 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RCN1: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Belongs to the CREC family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 11p13 Cellular Component: endoplasmic reticulum Molecular Function:protein binding |
| NCBI Summary: | Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009] |
| UniProt Code: | Q15293 |
| NCBI GenInfo Identifier: | 2493462 |
| NCBI Gene ID: | 5954 |
| NCBI Accession: | Q15293.1 |
| UniProt Secondary Accession: | Q15293,B7Z1M1, D3DR00, |
| UniProt Related Accession: | Q15293 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | Reticulocalbin-1 |
| NCBI Synonym Full Names: | reticulocalbin 1 |
| NCBI Official Symbol: | RCN1�� |
| NCBI Official Synonym Symbols: | RCN; RCAL; PIG20; HEL-S-84�� |
| NCBI Protein Information: | reticulocalbin-1 |
| UniProt Protein Name: | Reticulocalbin-1 |
| Protein Family: | Reticulocalbin |
| UniProt Gene Name: | RCN1�� |
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