Human RCAN2 Recombinant Protein (RPPB4426)

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SKU:
RPPB4426
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q14206

Description

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Product Name:Human RCAN2 Recombinant Protein
Product Code:RPPB4426
Size:20µg
Species:Human
Target:RCAN2
Synonyms:Regulator of calcineurin 2, DSCR1L1, MCIP2, Down syndrome critical region gene 1-like 1, ZAKI4, Myocyte-enriched calcineurin-interacting protein 2, Thyroid hormone-responsive protein ZAKI-4, CSP2, RCN2, thyroid hormone-responsive (skin fibroblasts).
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RCAN2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 200mM NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN

RCAN2 is a member of the RCAN (Regulator of calcineurin) family that controls the activity of Calcineurin using a valine-rich region placed in their carboxyl tail. RCANs race against NFAT (nuclear factor of activated T-cells) to bind to the same docking site in calcineurin, and consequently inhibits or activates calcineurin activity. RCAN2 is a Ca(2+) dependent protein phosphatase which takes part in numerous neuornal functions.

RCAN2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 217 amino acids (1-197 a.a.) and having a molecular mass of 24.1kDa.RCAN2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 6p12.3Cellular Component: cytoplasmMolecular Function: calcium-dependent protein serine/threonine phosphatase regulator activity
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q14206
NCBI GenInfo Identifier:158958336
NCBI Gene ID:10231
NCBI Accession:Q14206.3
UniProt Secondary Accession:Q14206,Q5VWF7, Q5VWF8, Q8N116, A6ND07, B3KR46
UniProt Related Accession:Q14206
Molecular Weight:27,289 Da
NCBI Full Name:Calcipressin-2
NCBI Synonym Full Names:regulator of calcineurin 2
NCBI Official Symbol:RCAN2��
NCBI Official Synonym Symbols:CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1��
NCBI Protein Information:calcipressin-2
UniProt Protein Name:Calcipressin-2
UniProt Synonym Protein Names:Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4
Protein Family:Calcipressin
UniProt Gene Name:RCAN2��
UniProt Entry Name:RCAN2_HUMAN
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