Human RCAN1 Recombinant Protein (RPPB4425)
- SKU:
- RPPB4425
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P53805
Description
| Product Name: | Human RCAN1 Recombinant Protein |
| Product Code: | RPPB4425 |
| Size: | 20µg |
| Species: | Human |
| Target: | RCAN1 |
| Synonyms: | Calcipressin-1, Regulator of calcineurin 1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, RCAN1, ADAPT78, CSP1, DSC1, DSCR1, RCN1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5, 100mM NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGPGEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS |
RCAN1 encoded by a gene located in the human chromosome 21, interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. RCAN1 is located in the minimal candidate region for the Down syndrome phenotype, and is over expressed in the brain of Down syndrome fetuses. Chronic over expression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development.
RCAN1 Isoform-b Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids and having a molecular mass of 13 kDa.
| UniProt Protein Function: | RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 21q22.12 Cellular Component: cytoplasm; nucleus Molecular Function:calcium-dependent protein serine/threonine phosphatase regulator activity; DNA binding; transcription factor activity Biological Process: blood circulation; central nervous system development; signal transduction |
| NCBI Summary: | The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
| UniProt Code: | P53805 |
| NCBI GenInfo Identifier: | 215274235 |
| NCBI Gene ID: | 1827 |
| NCBI Accession: | P53805.4 |
| UniProt Secondary Accession: | P53805,O00582, O00583, Q53XT0, Q6IBC6, Q7Z555, Q96R03 Q9BU69, Q9UF15, Q9UME4, D3DSF9, |
| UniProt Related Accession: | P53805 |
| Molecular Weight: | 13,291 Da |
| NCBI Full Name: | Calcipressin-1 |
| NCBI Synonym Full Names: | regulator of calcineurin 1 |
| NCBI Official Symbol: | RCAN1�� |
| NCBI Official Synonym Symbols: | CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78�� |
| NCBI Protein Information: | calcipressin-1 |
| UniProt Protein Name: | Calcipressin-1 |
| UniProt Synonym Protein Names: | Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1 |
| Protein Family: | Calcipressin |
| UniProt Gene Name: | RCAN1�� |
| UniProt Entry Name: | RCAN1_HUMAN |
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