Human RBP4 Recombinant Protein (RPES3926)
- SKU:
- RPES3926
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human RBP4 Recombinant Protein
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A); and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily; RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver; and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma; the RBP4-retinol complex interacts with transthyretin (TTR); and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes; and its deficiency affects night vision largely. Recently; RBP4 as an adipokine; is found to be expressed in adipose tissue and correlated with obesity; insulin resistance (IR) and type 2 diabetes (T2DM).
| Product Name: | Human RBP4 Recombinant Protein (RPES3926) |
| Product Code: | RPES3926 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | RDCCAS,Retinol-Binding Protein 4, Plasma Retinol-Binding Protein, PRBP, RBP, RBP4 |
| Accession: | NP_006735.2 |
| Sequence: | Met 1-Leu 201 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to bind all-trans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.The 50% binding concentration (BC50) is > 1.0 µM |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the pro form of human RBP4 (NP_006735.2) (Met 1-Leu 201) was expressed with a C-terminal polyhistidine tag. |
| Purity: | > 85 % as determined by reducing SDS-PAGE. |
| AP Mol Mass: | 23 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.2 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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