Human RBBP9 Recombinant Protein (RPPB4418)

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SKU:
RPPB4418
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75884

Description

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Product Name:Human RBBP9 Recombinant Protein
Product Code:RPPB4418
Size:20µg
Species:Human
Target:RBBP9
Synonyms:Retinoblastoma binding protein 9, RBBP-9, Retinoblastoma-binding protein 10, RBBP-10, BOG, B5T-overexpressed gene protein, putative hydrolase RBBP9, retinoma-binding protein 9.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RBBP9 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DRLETKLHKF TDCGHFQNTE FHELITVVKS LLKVPA

RBBP9, restricts to the nucleus and cytoplasm, is a retinoblastoma binding protein which takes part in the regulation of cell proliferation and differentiation. RBBP9 cooperates with retinoblastoma (Rb) and offers cellular resistance to the growth-inhibitory effects of TGFbeta1, therefore enabling the cellular transformation process.

RBBP9 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 206 amino acids (1-186 a.a.) and having a molecular mass of 23.1kDa.RBBP9 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RBBP9: May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1. Belongs to the RBBP9 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.-.-.-; Hydrolase

Chromosomal Location of Human Ortholog: 20p11.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function:hydrolase activity

Biological Process: metabolic process; regulation of cell proliferation

NCBI Summary:The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]
UniProt Code:O75884
NCBI GenInfo Identifier:18202147
NCBI Gene ID:10741
NCBI Accession:O75884.2
UniProt Secondary Accession:O75884,Q5JPH9, Q9H1D8, D3DW31,
UniProt Related Accession:O75884
Molecular Weight:186
NCBI Full Name:Putative hydrolase RBBP9
NCBI Synonym Full Names:retinoblastoma binding protein 9
NCBI Official Symbol:RBBP9��
NCBI Official Synonym Symbols:BOG; RBBP10��
NCBI Protein Information:putative hydrolase RBBP9; RBBP-9; RBBP-10; retinoma-binding protein 9; B5T overexpressed gene protein; B5T-overexpressed gene protein; retinoblastoma-binding protein 9; retinoblastoma-binding protein 10
UniProt Protein Name:Putative hydrolase RBBP9
UniProt Synonym Protein Names:B5T-overexpressed gene protein; Protein BOG; Retinoblastoma-binding protein 10; RBBP-10; Retinoblastoma-binding protein 9; RBBP-9
Protein Family:Putative hydrolase
UniProt Gene Name:RBBP9��
UniProt Entry Name:RBBP9_HUMAN
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